ArticleJournal of bacteriology2002
Respiration-dependent utilization of sugars in yeasts: a determinant role for sugar transporters.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 64 citations in OpenAlex.
- A constricted mitochondrial morphology formed during respiration.Nature communications · 2025Article
- Evolution and functional diversification of yeast sugar transporters.Essays in biochemistry · 2023Article
- Enhancing the Heterologous Fructosyltransferase Activity ofFrontiers in bioengineering and biotechnology · 2020Article
- Construction and characterization of a Saccharomyces cerevisiae strain able to grow on glucosamine as sole carbon and nitrogen source.Scientific reports · 2018Article
- A phylogenetic analysis of macroevolutionary patterns in fermentative yeasts.Ecology and evolution · 2016Article
- Opuntia ficus-indica cladodes as feedstock for ethanol production by Kluyveromyces marxianus and Saccharomyces cerevisiae.World journal of microbiology & biotechnology · 2014Article
- Article
- Expansion of hexose transporter genes was associated with the evolution of aerobic fermentation in yeasts.Molecular biology and evolution · 2011Article
- Transcriptional regulation of carbohydrate metabolism in the human pathogen Candida albicans.PLoS pathogens · 2009Article
- Switching the mode of sucrose utilization by Saccharomyces cerevisiae.Microbial cell factories · 2008Article
- Transcriptomic analysis of extensive changes in metabolic regulation in Kluyveromyces lactis strains.Eukaryotic cell · 2006Article
- Saccharomyces cerevisiae engineered for xylose metabolism exhibits a respiratory response.Applied and environmental microbiology · 2004Article
- Role of hexose transport in control of glycolytic flux in Saccharomyces cerevisiae.Applied and environmental microbiology · 2004Article
- Two distinct pathways for trehalose assimilation in the yeast Saccharomyces cerevisiae.Applied and environmental microbiology · 2004Article
- An example of the prisoner's dilemma in biochemistry.Die Naturwissenschaften · 2003Article
- Why does the yeast Kluyveromyces wickerhamii assimilates but not ferments lactose?Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many yeast species, including Kluyveromyces lactis, growth on certain sugars (such as galactose, raffinose, and maltose) occurs only under respiratory conditions. If respiration is blocked by inhibitors, mutation, or anaerobiosis, growth does not take place. This apparent dependence on respiration for the utilization of certain sugars has often been suspected to be associated with the mechanism of the sugar uptake step. We hypothesized that in many yeast species, the permease activities for these sugars are not sufficient to ensure the high substrate flow that is necessary for fermentative growth. By introducing additional sugar permease genes, we have obtained K. lactis strains that were capable of growing on galactose and raffinose in the absence of respiration. High dosages of both the permease and maltase genes were indeed necessary for K. lactis cells to grow on maltose in the absence of respiration. These results strongly suggest that the sugar uptake step is the major bottleneck in the fermentative assimilation of certain sugars in K. lactis and probably in many other yeasts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.