ArticleHeart (British Cardiac Society)2002
Taking up regular drinking in middle age: effect on major coronary heart disease events and mortality.
Article in Heart (British Cardiac Society), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Determinants of systemic hypertension in older adults in Africa: a systematic review.BMC cardiovascular disorders · 2019Pooled it
- Pooled it
- Ischemic heart disease mortality and morbidity rates in former drinkers: a meta-analysis.American journal of epidemiology · 2011Pooled it
- The Clustering of World Countries Regarding Causes of Death and Health Risk Factors.Iranian journal of public health · 2018Article
- Five year change in alcohol intake and risk of breast cancer and coronary heart disease among postmenopausal women: prospective cohort study.BMJ (Clinical research ed.) · 2016Article
- The good, the bad, and the ugly with alcohol use and abuse on the heart.Alcoholism, clinical and experimental research · 2013Review
- The impact of inflammation on cognitive function in older adults: implications for healthcare practice and research.The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses · 2012Review
- Heavy drinking occasions in relation to ischaemic heart disease mortality-- an 11-22 year follow-up of the 1984 and 1995 US National Alcohol Surveys.International journal of epidemiology · 2011Article
- Article
- Assessing the impact of medication use on trends in major coronary risk factors in older British men: a cohort study.European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology · 2010Article
- How does variability in alcohol consumption over time affect the relationship with mortality and coronary heart disease?Addiction (Abingdon, England) · 2010Article
- Article
- [Moderate alcohol consumption and mortality for various reasons].Atencion primaria · 2005Review
- Influence of alcohol consumption on restenosis rate after percutaneous transluminal coronary angioplasty and stent implantation.Heart (British Cardiac Society) · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine effects of taking up regular drinking by middle aged non-drinkers and occasional drinkers on major coronary heart disease events and total mortality.
methodsA prospective study of 7735 men from general practices in 24 British towns screened in 1978-80 at age 40-59 years (Q1). Five years after screening, 7157 men then aged 45-64 completed postal questionnaires (Q5) on changes in alcohol intake.
resultsIn 6503 men without diagnosed coronary heart disease, there were 874 major coronary heart disease events and 1613 total deaths during 16.8 years of follow up after Q5. With stable occasional drinkers as baseline, men who continued to drink regularly had a significantly lower risk of major coronary heart disease events, coronary heart disease mortality, and overall cardiovascular mortality, but a slightly increased risk of non-cardiovascular mortality. New regular drinkers (89% light), even after adjustment for their many advantageous characteristics, showed a lower risk of major coronary heart disease events than stable occasional drinkers (relative risk (RR) = 0.70; 95% confidence interval (CI) 0.48 to 1.03; p = 0.07). New drinkers showed no reduction in coronary heart disease or cardiovascular mortality and experienced an increase in risk of non-cardiovascular mortality (RR = 1.40; 95% CI 0.99 to 1.97; p = 0.06). In 654 men with diagnosed coronary heart disease, new drinkers experienced no mortality benefit compared with stable occasional drinkers.
conclusionsMiddle aged new regular drinkers experienced lower risk of major coronary heart disease events than stable occasional drinkers or non-drinkers, but had increased risk of non-cardiovascular mortality and total mortality. These findings provide little support for encouraging older men who do not drink or who only drink occasionally to take up regular drinking, whether or not they have coronary heart disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.