ArticleEMBO reports2002
The [URE3] phenotype: evidence for a soluble prion in yeast.
Article in EMBO reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Real-time imaging of yeast cells reveals several distinct mechanisms of curing of the [URE3] prion.The Journal of biological chemistry · 2018Article
- Prions in yeast.Genetics · 2012Review
- Prion dynamics and the quest for the genetic determinant in protein-only inheritance.Current opinion in microbiology · 2009Review
- The cellular concentration of the yeast Ure2p prion protein affects its propagation as a prion.Molecular biology of the cell · 2009Article
- Application of GFP-labeling to study prions in yeast.Protein and peptide letters · 2009Review
- The number and transmission of [PSI] prion seeds (Propagons) in the yeast Saccharomyces cerevisiae.PloS one · 2009Article
- Role for Hsp70 chaperone in Saccharomyces cerevisiae prion seed replication.Eukaryotic cell · 2005Article
- Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The mechanisms of [URE3] prion elimination demonstrate that large aggregates of Ure2p are dead-end products.The EMBO journal · 2003Article
- Internal initiation drives the synthesis of Ure2 protein lacking the prion domain and affects [URE3] propagation in yeast cells.The EMBO journal · 2003Article
- Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+].Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Antagonistic interactions between yeast [PSI(+)] and [URE3] prions and curing of [URE3] by Hsp70 protein chaperone Ssa1p but not by Ssa2p.Molecular and cellular biology · 2002Article
- Amyloid aggregates of the HET-s prion protein are infectious.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aggregation of the two yeast proteins Sup35p and Ure2p is widely accepted as a model for explaining the prion propagation of the phenotypes [PSI+] and [URE3], respectively. Here, we demonstrate that the propagation of [URE3] cannot simply be the consequence of generating large aggregates of Ure2p, because such aggregation can be found in some conditions that are not related to the prion state of Ure2p. A comparison of [PSI+] and [URE3] aggregation demonstrates differences between these two prion mechanisms. Our findings lead us to propose a new unifying model for yeast prion propagation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.