ArticleBiophysical journal2002
Diffusion of exchangeable water in cortical bone studied by nuclear magnetic resonance.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 101 citations in OpenAlex.
- "One-stop-shop" medical imaging for osteoporosis and obese patients: a narrative review.Journal of endocrinological investigation · 2026Review
- Assessing the osseointegration potential of a strontium releasing nanostructured titanium oxide surface: A biomechanical study in the rabbit tibia plateau model.Clinical and experimental dental research · 2024Article
- 3D Tortuosity and Diffusion Characterization in the Human Mineralized Collagen Fibril Using a Random Walk Model.Bioengineering (Basel, Switzerland) · 2023Article
- Extracellular ATP and its derivatives provide spatiotemporal guidance for bone adaptation to wide spectrum of physical forces.Bone reports · 2022Review
- Diffusion MRI for Assessment of Bone Quality; A Review of Findings in Healthy Aging and Osteoporosis.Journal of magnetic resonance imaging : JMRI · 2020Review
- Magnetic Resonance Imaging of Hard Tissues and Hard Tissue Engineered Bio-substitutes.Molecular imaging and biology · 2019Review
- Fractal-like hierarchical organization of bone begins at the nanoscale.Science (New York, N.Y.) · 2018Article
- Solute Transport in the Bone Lacunar-Canalicular System (LCS).Current osteoporosis reports · 2018Review
- The Behavior of Water in Collagen and Hydroxyapatite Sites of Cortical Bone: Fracture, Mechanical Wear, and Load Bearing Studies.The journal of physical chemistry. C, Nanomaterials and interfaces · 2015Article
- The Role of Water Compartments in the Material Properties of Cortical Bone.Calcified tissue international · 2015Review
- Article
- Experimental study of diffusion coefficients of water through the collagen: apatite porosity in human trabecular bone tissue.BioMed research international · 2014Article
- Qualitative and quantitative ultrashort-TE MRI of cortical bone.NMR in biomedicine · 2013Review
- Magnetic resonance of calcified tissues.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2013Review
- Deuterium nuclear magnetic resonance unambiguously quantifies pore and collagen-bound water in cortical bone.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
- Clinically compatible MRI strategies for discriminating bound and pore water in cortical bone.Magnetic resonance in medicine · 2012Article
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- Ultrashort TE MR imaging of bovine cortical bone: the effect of water loss on the T1 and T2* relaxation times.Magnetic resonance in medicine · 2011Article
- Numerical modeling of oxygen distributions in cortical and cancellous bone: oxygen availability governs osteonal and trabecular dimensions.American journal of physiology. Cell physiology · 2010Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rate-limiting step in the delivery of nutrients to osteocytes and the removal of cellular waste products is likely diffusion. The transport of osteoid water across the mineralized matrix of bone was studied by proton nuclear magnetic resonance spectroscopy and imaging by measuring the diffusion fluxes of tissue water in cortical bone specimens from the midshaft of rabbit tibiae immersed in deuterium oxide. From the diffusion coefficient (D(a) = (7.8 +/- 1.5) x 10(-7) cm(2)/s) measured at 40 degrees C (close to physiological temperature), it can be inferred that diffusive transport of small molecules from the bone vascular system to the osteocytes occurs within minutes. The activation energy for water diffusion, calculated from D(a) measured at four different temperatures, suggests that the interactions between water molecules and matrix pores present significant energy barriers to diffusion. The spatially resolved profile of D(a) perpendicular to the cortical surface of the tibia, obtained using a finite difference model, indicates that diffusion rates are higher close to the endosteal and periosteal surfaces, decreasing toward the center of the cortex. Finally, the data reveal a water component (approximately 30%) diffusing four orders of magnitude more slowly, which is ascribed to water tightly bound to the organic matrix and mineral phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.