ArticleBiophysical journal2002
Heterogeneous nucleation and crowding in sickle hemoglobin: an analytic approach.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Discovery of Osivelotor (GBT021601): A Potent, Next-Generation Sickle Hemoglobin Polymerization Inhibitor.ACS medicinal chemistry letters · 2025Article
- Biophysical chemistry behind sickle cell anemia and the mechanism of voxelotor action.Scientific reports · 2024Article
- An α-chain modification rivals the effect of fetal hemoglobin in retarding the rate of sickle cell fiber formation.Scientific reports · 2023Article
- Voxelotor does not inhibit sickle hemoglobin fiber formation upon complete deoxygenation.Biophysical journal · 2023Article
- The Sickle-Cell Fiber Revisited.Biomolecules · 2023Review
- Impact of hemoglobin biophysical studies on molecular pathogenesis and drug therapy for sickle cell disease.Molecular aspects of medicine · 2022Review
- Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Deciphering Copper Coordination in the Mammalian Prion Protein Amyloidogenic Domain.Biophysical journal · 2020Article
- Theoretical Simulation of Red Cell Sickling Upon Deoxygenation Based on the Physical Chemistry of Sickle Hemoglobin Fiber Formation.The journal of physical chemistry. B · 2018Article
- Potential of Three Ethnomedicinal Plants as Antisickling Agents.Molecular pharmaceutics · 2017Article
- Universality of supersaturation in protein-fiber formation.Nature structural & molecular biology · 2016Article
- Article
- Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations.The Journal of chemical physics · 2011Article
- Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments.The Journal of chemical physics · 2011Article
- Paradoxical acceleration of dithiothreitol-induced aggregation of insulin in the presence of a chaperone.International journal of molecular sciences · 2010Article
- Band 3 catalyzes sickle hemoglobin polymerization.Biophysical chemistry · 2010Article
- Metastable polymerization of sickle hemoglobin in droplets.Journal of molecular biology · 2007Article
- Heterogeneous nucleation in sickle hemoglobin: experimental validation of a structural mechanism.Biophysical journal · 2005Article
- Understanding the shape of sickled red cells.Biophysical journal · 2005Article
- Life in a crowded world.EMBO reports · 2004Article
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Authors and funding
3 authors.
Funding
Abstract
Sickle hemoglobin nucleation occurs in solution as a homogeneous process or on existing polymers in a heterogeneous process. We have developed an analytic formulation to describe the solution crowding and large nonideality that affects the heterogeneous nucleation of sickle hemoglobin by using convex particle theory. The formulation successfully fits the concentration and temperature dependence of the heterogeneous nucleation process over 14 orders of magnitude. Unlike previous approaches, however, the new formulation can also accurately describe the effects of adding nonpolymerizing agents to the solution. Without additional adjustable parameters, the model now describes the data of M. Ivanova, R. Jasuja, S. Kwong, R. W. Briehl, and F. A. Ferrone, (Biophys. J. 2000, 79:1016-1022), in which up to 50% of the sickle hemoglobin is substituted by cross-linked hemoglobin A, which does not polymerize, and which substitution causes the rates to decrease by 10(5). The success of this approach provides insight into the polymerization process: from the size-dependence of the contact energy deduced here, it also appears that various contacts of unknown origin are energetically significant in the heterogeneous nucleation process.
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