ArticleBiophysical journal2002
Periodicity, mixed-mode oscillations, and quasiperiodicity in a rhythm-generating neural network.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- COVID-19 and silent hypoxemia in a minimal closed-loop model of the respiratory rhythm generator.Biological cybernetics · 2024Article
- Microcircuit Synchronization and Heavy-Tailed Synaptic Weight Distribution Augment preBötzinger Complex Bursting Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Temporal variations in the pattern of breathing: techniques, sources, and applications to translational sciences.The journal of physiological sciences : JPS · 2022Review
- Article
- Effect of spontaneous movement on respiration in preterm infants.Experimental physiology · 2021Article
- Automated Classification of Whole Body Plethysmography Waveforms to Quantify Breathing Patterns.Frontiers in physiology · 2021Article
- Emergent Dynamics and Spatio Temporal Patterns on Multiplex Neuronal Networks.Frontiers in computational neuroscience · 2021Article
- Reduced computational modelling of Kölliker-Fuse contributions to breathing patterns in Rett syndrome.The Journal of physiology · 2019Article
- Coupling of autonomic and central events during sleep benefits declarative memory consolidation.Neurobiology of learning and memory · 2019Article
- Article
- Facing the challenge of mammalian neural microcircuits: taking a few breaths may help.The Journal of physiology · 2015Review
- Neural mechanisms underlying breathing complexity.PloS one · 2013Article
- A method for analyzing temporal patterns of variability of a time series from Poincare plots.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Computational models and emergent properties of respiratory neural networks.Comprehensive Physiology · 2012Review
- Assessment of cardio-respiratory interactions in preterm infants by bivariate autoregressive modeling and surrogate data analysis.Early human development · 2011Article
- The role of spiking and bursting pacemakers in the neuronal control of breathing.Journal of biological physics · 2011Article
- Effects of maturation and acidosis on the chaos-like complexity of the neural respiratory output in the isolated brainstem of the tadpole, Rana esculenta.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Ventilatory chaos is impaired in carotid atherosclerosis.PloS one · 2011Article
- Study of multiparameter respiratory pattern complexity in surgical critically ill patients during weaning trials.BMC physiology · 2011Article
- Rhythmogenic neuronal networks, emergent leaders, and k-cores.Physical review. E, Statistical, nonlinear, and soft matter physics · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied patterns of oscillatory neural activity in the network that generates respiratory rhythm in mammals. When isolated in vitro, this network spontaneously generates an inspiratory-related motor rhythm, with stable amplitude from cycle to cycle. We show that progressively elevating neuronal excitability in vitro causes periodic modulation of this inspiratory rhythm, evoking (in order): mixed-mode oscillations, quasiperiodicity, and ultimately disorganized aperiodic activity. Thus, the respiratory network oscillator follows a well defined sequence of behavioral states characterized by dynamical systems theory, which includes discrete stages of periodic and quasiperiodic amplitude modulation and progresses (according to theory) to aperiodic chaos-like behavior. We also observed periodic, mixed-mode periodic, and quasiperiodic breathing patterns in neonatal rodents and human infants in vivo, suggesting that breathing patterns generated by the intact nervous system reflect deterministic neural activity patterns in the underlying rhythm-generating network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.