ArticleBiophysical journal2002
Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 141 citations in OpenAlex.
- Dynamic hierarchical ligand anisotropy for competing macrophage regulationBioactive materials · 2025Article
- Role of Cell Adhesion in Cancer Metastasis Formation: A Review.ACS omega · 2025Review
- Mechanistic Insights into Membrane Protein Clustering Revealed by Visualizing EGFR Secretion.Research (Washington, D.C.) · 2022Article
- Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction.Frontiers in cell and developmental biology · 2022Review
- Win, Lose, or Tie: Mathematical Modeling of Ligand Competition at the Cell-Extracellular Matrix Interface.Frontiers in bioengineering and biotechnology · 2021Article
- Effect of TiONanomaterials (Basel, Switzerland) · 2020Article
- Integrin Subtypes and Nanoscale Ligand Presentation Influence Drug Sensitivity in Cancer Cells.Nano letters · 2020Article
- Multiscale model of integrin adhesion assembly.PLoS computational biology · 2019Article
- Computational model of wound healing: EGF secreted by fibroblasts promotes delayed re-epithelialization of epithelial keratinocytes.Integrative biology : quantitative biosciences from nano to macro · 2018Article
- Multivalent Binding of a Ligand-Coated Particle: Role of Shape, Size, and Ligand Heterogeneity.Biophysical journal · 2018Article
- Janus Nanoparticles for T Cell Activation: Clustering Ligands to Enhance Stimulation.Journal of materials chemistry. B · 2017Article
- On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks.Biomaterials · 2017Article
- Nanoscale physicochemical properties of chain- and step-growth polymerized PEG hydrogels affect cell-material interactions.Journal of biomedical materials research. Part A · 2017Article
- Use of protein-engineered fabrics to identify design rules for integrin ligand clustering in biomaterials.Integrative biology : quantitative biosciences from nano to macro · 2016Article
- Sundew adhesive: a naturally occurring hydrogel.Journal of the Royal Society, Interface · 2015Article
- In PC3 prostate cancer cells ephrin receptors crosstalk to β1-integrins to strengthen adhesion to collagen type I.Scientific reports · 2015Article
- Synthetic Extracellular Microenvironment for Modulating Stem Cell Behaviors.Biomarker insights · 2015Review
- An Engineered N-Cadherin Substrate for Differentiation, Survival, and Selection of Pluripotent Stem Cell-Derived Neural Progenitors.PloS one · 2015Article
- Engineered biomaterials control differentiation and proliferation of human-embryonic-stem-cell-derived cardiomyocytes via timed Notch activation.Stem cell reports · 2014Article
- Advancements in stem cells treatment of skeletal muscle wasting.Frontiers in physiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Clustering of ligated integrins strongly influences integrin signaling and mechanical linkages between integrins and intracellular structures. Extracellular spatial organization of integrin ligands in clusters may facilitate clustering of bound integrins and thus potentially regulate cellular responses to a defined average amount of ligand in the extracellular environment. The possible role of such ligand clustering effects in controlling overall receptor occupancy is studied here using a simple mass-action equilibrium model as well as a two-dimensional Monte Carlo lattice description of the cell-substrate interface, where cell surface receptors are free to diffuse in the plane of the interface and interact with the substrate-immobilized ligand. Results from the analytical treatment and simulation data indicate that for a single-state model in which receptor-ligand binding equilibria are not influenced by neighboring complexes, clustering of ligand does not enhance total receptor binding. However, if receptor binding energy increases in the presence of neighboring ligated receptors, strong ligand spatial distribution effects arise. Nonlinear responses to increasing ligand density are also observed even in the case of random ligand placement due to stochastic juxtaposition of ligand molecules. These results describe how spatial distribution of ligand presented by the extracellular matrix or by synthetic biomimetic materials might control cell responses to external ligands, and suggest a feedback mechanism by which focal contact formation might be initiated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.