ArticleBiophysical journal2002
Modeling hair cell tuning by expression gradients of potassium channel beta subunits.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- The potassium channel subunit KeLife · 2024Article
- The potassium channel subunit KbioRxiv : the preprint server for biology · 2024Article
- Alternative splicing in shaping the molecular landscape of the cochlea.Frontiers in cell and developmental biology · 2023Review
- Diverse Mechanisms of Sound Frequency Discrimination in the Vertebrate Cochlea.Trends in neurosciences · 2020Review
- Presynaptic BK channels control transmitter release: physiological relevance and potential therapeutic implications.The Journal of physiology · 2016Review
- Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.Nature communications · 2014Article
- A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear.Nature communications · 2014Article
- Electrical tuning and transduction in short hair cells of the chicken auditory papilla.Journal of neurophysiology · 2013Article
- Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol.Pharmacology & therapeutics · 2012Review
- Highly specific alternative splicing of transcripts encoding BK channels in the chicken's cochlea is a minor determinant of the tonotopic gradient.Molecular and cellular biology · 2010Article
- Developmental expression of BK channels in chick cochlear hair cells.BMC developmental biology · 2009Article
- Tamoxifen inhibits BK channels in chick cochlea without alterations in voltage-dependent activation.American journal of physiology. Cell physiology · 2009Article
- Hair-cell versus afferent adaptation in the semicircular canals.Journal of neurophysiology · 2005Article
- Variation in large-conductance, calcium-activated potassium channels from hair cells along the chicken basilar papilla.The Journal of physiology · 2003Article
- A BK (Slo1) channel journey from molecule to physiology.Channels (Austin, Tex.)Review
- Hair cells--beyond the transducer.The Journal of membrane biologyReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The receptor potential of sensory hair cells arises from the gating of mechanosensitive cation channels, but its amplitude and time course also depend on the number and kinetics of voltage-gated ion channels in each cell. Prominent among these are "BK" potassium channels encoded by the slo gene that support electrical tuning in some hair cells. Hair cells tuned to low frequencies have slowly gating BK channels, whereas those of higher-frequency hair cells gate more rapidly. Alternative splicing of the slo gene mRNA that encodes the pore-forming alpha subunit can alter BK channel kinetics, and gating is dramatically slowed by coexpression with modulatory beta subunits. The effect of the beta subunit is consistent with low-frequency tuning, and beta mRNA is expressed at highest levels in the low frequency apex of the bird's auditory epithelium. How might an expression gradient of beta subunits contribute to hair cell tuning? The present work uses a computational model of hair cell-tuning based on the functional properties of BK channels expressed from hair cell alpha and beta slo cDNA. The model reveals that a limited tonotopic gradient could be achieved simply by altering the fraction of BK channels in each hair cell that are combined with beta subunits. However, complete coverage of the tuning spectrum requires kinetic variants in addition to those modeled here.
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