ArticleBiophysical journal2002
Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 194 papers.
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194 citing papers in PubMed.
- Computational insights on the interplay between electrotaxis and mechanotaxis.PLoS computational biology · 2026Article
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- Investigating local negative feedback of Rac activity by mathematical models and cell-motility simulations.iScience · 2026Article
- Trainable computation in molecular networks.bioRxiv : the preprint server for biology · 2025Article
- Emergent eukaryotic directional sensing via receptor degradation and diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cumulative dose responses for adapting biological systems.Journal of the Royal Society, Interface · 2025Article
- Competing signaling pathways controls electrotaxis.iScience · 2025Article
- Traveling-wave chemotaxis of neutrophil-like HL-60 cells.Molecular biology of the cell · 2025Article
- Information bounds on the accuracy of cell polarization.PloS one · 2025Article
- Modelling the effect of cell motility on mixing and invasion in epithelial monolayers.Journal of biological physics · 2024Article
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- Spontaneous signal generation by an excitable system for cell migration.Frontiers in cell and developmental biology · 2024Review
- Single-cell directional sensing from just a few receptor binding events.Biophysical journal · 2023Article
- Non-asymptotic transients away from steady states determine cellular responsiveness to dynamic spatial-temporal signals.PLoS computational biology · 2023Article
- Evolutionary Stability of Small Molecular Regulatory Networks That Exhibit Near-Perfect Adaptation.Biology · 2023Article
- Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis.The EMBO journal · 2023Article
- Short-time diffusive fluxes over membrane receptors yields the direction of a signalling source.Royal Society open science · 2023Article
- Protein-protein complexes can undermine ultrasensitivity-dependent biological adaptation.Journal of the Royal Society, Interface · 2023Article
- Signal amplification in growth cone gradient sensing by a double negative feedback loop among PTEN, PI(3,4,5)PMolecular and cellular neurosciences · 2022Article
- Universal structural requirements for maximal robust perfect adaptation in biomolecular networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
134 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic cells can detect shallow gradients of chemoattractants with exquisite precision and respond quickly to changes in the gradient steepness and direction. Here, we describe a set of models explaining both adaptation to uniform increases in chemoattractant and persistent signaling in response to gradients. We demonstrate that one of these models can be mapped directly onto the biochemical signal-transduction pathways underlying gradient sensing in amoebae and neutrophils. According to this scheme, a locally acting activator (PI3-kinase) and a globally acting inactivator (PTEN or a similar phosphatase) are coordinately controlled by the G-protein activation. This signaling system adapts perfectly to spatially homogeneous changes in the chemoattractant. In chemoattractant gradients, an imbalance between the action of the activator and the inactivator results in a spatially oriented persistent signaling, amplified by a substrate supply-based positive feedback acting through small G-proteins. The amplification is activated only in a continuous presence of the external signal gradient, thus providing the mechanism for sensitivity to gradient alterations. Finally, based on this mapping, we make predictions concerning the dynamics of signaling. We propose that the underlying principles of perfect adaptation and substrate supply-based positive feedback will be found in the sensory systems of other chemotactic cell types.
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