ArticleAntimicrobial agents and chemotherapy2002
Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection.
Article in Antimicrobial agents and chemotherapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Phase I trial of the polyamine analog N1,N14-diethylhomospermine (DEHSPM) in patients with advanced solid tumors.Investigational new drugs · 2004Trial
- Defence Warriors: Exploring the crosstalk between polyamines and oxidative stress during microbial pathogenesis.Redox biology · 2025Review
- Current Therapy and Therapeutic Targets for Microsporidiosis.Frontiers in microbiology · 2022Review
- Encephalitozoon: Tissue Culture, Cryopreservation, and Murine Infection.Current protocols in microbiology · 2019Article
- Novel Synthetic Polyamines Have Potent Antimalarial ActivitiesFrontiers in cellular and infection microbiology · 2019Article
- Therapeutic targets for the treatment of microsporidiosis in humans.Expert opinion on therapeutic targets · 2018Review
- Article
- Perturbation of spermine synthase gene expression and transcript profiling provide new insights on the role of the tetraamine spermine in Arabidopsis defense against Pseudomonas viridiflava.Plant physiology · 2011Article
- Probing tRNA interaction with biogenic polyamines.RNA (New York, N.Y.) · 2010Article
- Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi.Antimicrobial agents and chemotherapy · 2009Article
- Apoplastic polyamine oxidation plays different roles in local responses of tobacco to infection by the necrotrophic fungus Sclerotinia sclerotiorum and the biotrophic bacterium Pseudomonas viridiflava.Plant physiology · 2008Article
- Efficacy of gamma interferon and specific antibody for treatment of microsporidiosis caused by Encephalitozoon cuniculi in SCID mice.Antimicrobial agents and chemotherapy · 2008Article
- Polyamine analogues bind human serum albumin.Biomacromolecules · 2007Article
- Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells.The Journal of biological chemistry · 2006Article
- Diarrhea in patients with AIDS.Current treatment options in gastroenterology · 2006Article
- Role of p53/p21(Waf1/Cip1) in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells.Cancer biology & therapy · 2005Article
- In vitro effects of resveratrol on the viability and infectivity of the microsporidian Encephalitozoon cuniculi.Antimicrobial agents and chemotherapy · 2004Article
- Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues.Microbiology (Reading, England) · 2004Article
- A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2003Article
- Polyamine metabolism and cancer.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocompromised hosts, such as patients with AIDS or patients who have undergone organ transplantation. We have demonstrated in vitro and in vivo that synthetic polyamine analogs are effective antimicrosporidial agents with a broad therapeutic window. CD8-knockout mice or nude mice infected with the microsporidian Encephalitozoon cuniculi were cured when they were treated with four different novel polyamine analogs at doses ranging from 1.25 to 5 mg/kg of body weight/day for a total of 10 days. Cured animals demonstrated no evidence of parasitemia by either PCR or histologic staining of tissues 30 days after untreated control animals died.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.