ArticleThe Journal of cell biology2001
MuSK induces in vivo acetylcholine receptor clusters in a ligand-independent manner.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Manufacturing, Cell Regulation, and Coculture Strategies for Vascularization and Neural Innervation of Skeletal Muscle Tissue.Advanced healthcare materials · 2026Review
- Gene-specific response to muscle specific kinase agonist antibody in the treatment of congenital myasthenic syndromes.Brain communications · 2026Article
- Respiratory characterization of a humanized Duchenne muscular dystrophy mouse model.Respiratory physiology & neurobiology · 2024Article
- The MouseFrontiers in cellular neuroscience · 2020Article
- Nerve, Muscle, and Synaptogenesis.Cells · 2019Review
- Forced expression of muscle specific kinase slows postsynaptic acetylcholine receptor loss in a mouse model of MuSK myasthenia gravis.Physiological reports · 2015Article
- Rapid diaphragm atrophy following cervical spinal cord hemisection.Respiratory physiology & neurobiology · 2014Article
- Altered active zones, vesicle pools, nerve terminal conductivity, and morphology during experimental MuSK myasthenia gravis.PloS one · 2014Article
- Article
- Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- MuSK controls where motor axons grow and form synapses.Nature neuroscience · 2008Article
- MuSK is required for anchoring acetylcholinesterase at the neuromuscular junction.The Journal of cell biology · 2004Article
- Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Nerve-independent formation of a topologically complex postsynaptic apparatus.The Journal of cell biology · 2004Article
- A role for the juxtamembrane domain of beta-dystroglycan in agrin-induced acetylcholine receptor clustering.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Laminin-1 redistributes postsynaptic proteins and requires rapsyn, tyrosine phosphorylation, and Src and Fyn to stably cluster acetylcholine receptors.The Journal of cell biology · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle-specific receptor tyrosine kinase (MuSK) is required for the formation of the neuromuscular junction. Using direct gene transfer into single fibers, MuSK was expressed extrasynaptically in innervated rat muscle in vivo to identify its contribution to synapse formation. Spontaneous MuSK kinase activity leads, in the absence of its putative ligand neural agrin, to the appearance of epsilon-subunit-specific transcripts, the formation of acetylcholine receptor clusters, and acetylcholinesterase aggregates. Expression of kinase-inactive MuSK did not result in the formation of acetylcholine receptor (AChR) clusters, whereas a mutant MuSK lacking the ectodomain did induce AChR clusters. The contribution of endogenous MuSK was excluded by using genetically altered mice, where the kinase domain of the MuSK gene was flanked by loxP sequences and could be deleted upon expression of Cre recombinase. This allowed the conditional inactivation of endogenous MuSK in single muscle fibers and prevented the induction of ectopic AChR clusters. Thus, the kinase activity of MuSK initiates signals that are sufficient to induce the formation of AChR clusters. This process does not require additional determinants located in the ectodomain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.