Evidence map›Paper›PMID 11748211›Full record

ArticleInfection and immunity2002

STK receptor tyrosine kinase regulates susceptibility to infection with Listeria monocytogenes.

Michael A Lutz, Francine Gervais, Alan Bernstein, Arthur L Hattel, Pamela H Correll

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Michael A LutzDepartment of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802-3500, USA.
Francine Gervais
Alan Bernstein
Arthur L Hattel
Pamela H Correll
Pennsylvania State University · USLunenfeld-Tanenbaum Research Institute · CAMontreal General Hospital · CA

Funding

MURINE STK RECEPTOR AND MACROPHAGE ACTIVATIONR29AI043367 · NIAID · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI HANKEY, PAMELA A · 1998 to 2002
$238k
NIAID NIH HHS AI43367NIAID NIH HHS R29 AI043367
6 · The paper itself

Abstract

We have previously identified the STK receptor tyrosine kinase as a key regulator of macrophage activation and cell-mediated immune responses. Here we demonstrate that, although MSP activation of STK inhibits NO production by macrophages in response to heat-killed Listeria monocytogenes, STK-deficient mice exhibit increased susceptibility to infection with Listeria.

Indexed as

Hepatocyte Growth FactorProto-Oncogene ProteinsAnimalsCells, CulturedDisease SusceptibilityGrowth SubstancesInterferon-gammaListeria monocytogenesListeriosisLiverMacrophages, PeritonealMiceMice, KnockoutNitric OxideReceptor Protein-Tyrosine KinasesReceptors, Cell SurfaceGrowth SubstancesHepatocyte Growth FactorInterferon-gammamacrophage stimulating proteinNitric OxideProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, Cell SurfaceRON protein

Identifiers

PMID11748211
PMCPMC127617
OpenAlexW2121620542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.