ArticleEnvironmental health perspectives2001
Organophosphorous pesticide exposure increases the frequency of sperm sex null aneuploidy.
Article in Environmental health perspectives, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- The environmental and occupational influence of pesticides on male fertility: A systematic review of human studies.Andrology · 2022Pooled it
- Non-cancer health effects of pesticides: systematic review and implications for family doctors.Canadian family physician Medecin de famille canadien · 2007Pooled it
- Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures.Heliyon · 2024Review
- Assessing the health hazard originated via pesticide chemicals in human through rabbit model in agricultural production system in Bangladesh.BMC pharmacology & toxicology · 2022Article
- A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico.Toxics · 2021Review
- Fate of chlorpyrifos, omethoate, cypermethrin, and deltamethrin during wheat milling and Chinese steamed bread processing.Food science & nutrition · 2021Article
- Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study.International journal of environmental research and public health · 2020Article
- Pesticide interactions and risks of sperm chromosomal abnormalities.International journal of hygiene and environmental health · 2019Article
- Aneuvis: web-based exploration of numerical chromosomal variation in single cells.BMC bioinformatics · 2019Article
- New Biological Insights on X and Y Chromosome-Bearing Spermatozoa.Frontiers in cell and developmental biology · 2019Review
- Individual and combined effect of chlorpyrifos and cypermethrin on reproductive system of adult male albino rats.Environmental science and pollution research international · 2017Article
- Parenteral exposure to pesticides and occurence of congenital malformations: hospital-based case-control study.BMC pediatrics · 2016Article
- Dialkyl phosphate urinary metabolites and chromosomal abnormalities in human sperm.Environmental research · 2015Article
- Environmental exposure to polychlorinated biphenyls and p,p'-DDE and sperm sex-chromosome disomy.Environmental health perspectives · 2012Article
- The use of fluorescent in situ hybridization in male infertility.Therapeutic advances in urology · 2010Article
- Employment in the Ecuadorian cut-flower industry and the risk of spontaneous abortion.BMC international health and human rights · 2009Article
- Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters.Environmental health : a global access science source · 2008Article
- Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: executive summary.Fertility and sterility · 2008Article
- Maternal and paternal occupational exposure to agricultural work and the risk of anencephaly.Occupational and environmental medicine · 2006Article
- Off to a good start: the influence of pre- and periconceptional exposures, parental fertility, and nutrition on children's health.Environmental health perspectives · 2004Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
It has been estimated that 4 of 1,000 live births and 35% of spontaneous abortions are aneuploid and that an important proportion of embryo and newborn aneuploidy is of paternal origin. Exposure to organophosphorous pesticides (OP) has been associated with sperm hyperploidy/polyploidy. Therefore, we aimed to assess the frequency of sperm aneuploidy (X, Y, and 18) and its relationship with urinary OP metabolites in agricultural workers. We performed multicolor fluorescence in situ hybridization on samples from nine men obtained before and during the pesticide spraying season to assess sperm aneuploidy. We measured urinary OP metabolite levels by gas-liquid chromatography. Aneuploidies were found in 0.67% of total sperm nuclei. The most frequent aneuploidy was the lack of a sexual chromosome or sex null (0.19%), followed by XY18 (0.15%) and XY18-18 (0.06%). OP metabolites detected at higher concentrations were dimethylthiophosphate, dimethyldithiophosphate, and diethylphosphate (DEP). There were no differences in average aneuploidy frequency or urinary metabolite levels between samples collected before and after exposure. However, Poisson regression analysis adjusted for age, alcohol intake, and sperm concentration showed significant associations between OP metabolite concentrations and increased frequency of sperm aneuploidies. The association was more evident between DEP and sex null, and the risk increased further during the spraying season. Thus, OP exposure could interfere with sperm chromosome segregation and increase the risk for genetic syndromes, such as Turner's. Further studies are required to assess the prevalence of spontaneous abortions, birth defects, and genetic syndromes in agricultural communities.
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