ArticleBMC cancer2001
Alterations of E-cadherin and beta-catenin in gastric cancer.
Article in BMC cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Pooled it
- Implementing an On-Slide Molecular Classification of Gastric Cancer: A Tissue Microarray Study.Cancers · 2023Article
- Current advances in understanding the molecular profile of hereditary diffuse gastric cancer and its clinical implications.Journal of experimental & clinical cancer research : CR · 2023Review
- CD36 and CD97 in Pancreatic Cancer versus Other Malignancies.International journal of molecular sciences · 2020Review
- Microsatellite Alterations and Protein Expression of 5 Major Tumor Suppressor Genes in Gastric Adenocarcinomas.Translational oncology · 2018Article
- Naturally occurring compounds acting as potent anti-metastatic agents and their suppressing effects on Hedgehog and WNT/β-catenin signalling pathways.Cell proliferation · 2017Review
- The prognostic value of β-catenin and LEF-1 expression in patients with operable gastric carcinoma.American journal of translational research · 2016Article
- Brief report: Dclk1 deletion in tuft cells results in impaired epithelial repair after radiation injury.Stem cells (Dayton, Ohio) · 2014Article
- Prognostic role of E-cadherin and Vimentin expression in various subtypes of soft tissue leiomyosarcomas.Medical oncology (Northwood, London, England) · 2013Article
- Prognostic significance of Wnt-1, β-catenin and E-cadherin expression in advanced colorectal carcinoma.Pathology oncology research : POR · 2011Article
- Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled.Molecular cancer · 2010Article
- Liquid chromatography-tandem and MALDI imaging mass spectrometry analyses of RCL2/CS100-fixed, paraffin-embedded tissues: proteomics evaluation of an alternate fixative for biomarker discovery.Journal of proteome research · 2009Article
- Clinicopathological significance of E-cadherin, β-catenin and p53 expression in gastric adenocarinoma.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2009Article
- The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients.British journal of cancer · 2008Article
- Epstein-Barr virus, beta-catenin, and E-cadherin in gastric carcinomas.Journal of Korean medical science · 2007Article
- Loss of heterozygosity testing using real-time PCR analysis of single nucleotide polymorphisms.Journal of cancer research and clinical oncology · 2006Article
- beta-Catenin expression in thyroid follicular lesions: potential role in nuclear envelope changes in papillary carcinomas.Endocrine pathology · 2004Review
- Expression of e-cadherin and beta-catenin in human esophageal squamous cell carcinoma: relationships with prognosis.World journal of gastroenterology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe E-cadherin-catenin complex plays a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. Perturbation in the expression or function of this complex results in loss of intercellular adhesion, with possible consequent cell transformation and tumour progression.
methodsWe studied the alterations of E-cadherin and beta-catenin in a set of 50 primary gastric tumours by using loss of heterozygosity (LOH) analysis, gene mutation screening, detection of aberrant transcripts and immunohistochemistry (IHC).
resultsA high frequency (75%) of LOH was detected at 16q22.1 containing E-cadherin locus. Three cases (6%) showed the identical missense mutation, A592T. This mutation is not likely to contribute strongly to the carcinogenesis of gastric cancer, because a low frequency (1.6%) of this mutation was also found in 187 normal individuals. We also detected a low frequency (0.36%, 0%) of this mutation in 280 breast tumours and 444 other tumours, including colon and rectum, lung, endometrium, ovary, testis, kidney, thyroid carcinomas and sarcomas, respectively. We also analyzed the aberrant E-cadherin mRNAs in the gastric tumours and found that 7 tumours (18%) had aberrant mRNAs in addition to the normal mRNA. These aberrant mRNAs may produce abnormal E-cadherin molecules, resulting in weak cell-cell adhesion and invasive behaviour of carcinoma cells. Reduced expression of E-cadherin and beta-catenin was identified at the frequency of 42% and 28%, respectively. Specially, 11 tumours (22%) exhibited positive cytoplasmic staining for beta-catenin IHC. An association was found between reduced expression of E-cadherin and beta-catenin. Moreover, an association was detected between reduced expression of E-cadherin and diffuse histotype.
conclusionOur results support the hypothesis that alterations of E-cadherin and beta-catenin play a role in the initiation and progression of gastric cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.