ArticleBMC neuroscience2001
Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices.
Article in BMC neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 33 citations in OpenAlex.
- Increased thrombospondin-1 levels contribute to epileptic susceptibility in neonatal hyperthermia without seizures via altered synaptogenesis.Cell death discovery · 2024Article
- Macromolecular rate theory explains the temperature dependence of membrane conductance kinetics.Biophysical journal · 2023Article
- Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice.Frontiers in pharmacology · 2023Article
- Origins of temporal lobe epilepsy: febrile seizures and febrile status epilepticus.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
- Global warming and neurodegenerative disorders: speculations on their linkage.BioImpacts : BI · 2014Article
- Acute exposure to the mitochondrial complex I toxin rotenone impairs synaptic long-term potentiation in rat hippocampal slices.CNS neuroscience & therapeutics · 2012Article
- Article
- High temperatures alter physiological properties of pyramidal cells and inhibitory interneurons in hippocampus.Frontiers in cellular neuroscience · 2012Article
- A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to febrile seizures in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Nonlinear dynamical analysis of carbachol induced hippocampal oscillations in mice.Acta pharmacologica Sinica · 2009Article
- Fever, febrile seizures and epilepsy.Trends in neurosciences · 2007Review
- Fever, Seizures and Encephalopathy: From Bush Fires to Firestorms.Annals of Indian Academy of NeurologyArticle
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5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently a hyperthermic rat hippocampal slice model system has been used to investigate febrile seizure pathophysiology. Our previous data indicates that heating immature rat hippocampal slices from 34 to 41 degrees C in an interface chamber induced epileptiform-like population spikes accompanied by a spreading depression (SD). This may serve as an in vitro model of febrile seizures.
resultsIn this study, we further investigate cellular mechanisms of hyperthermia-induced initial population spike activity. We hypothesized that GABA(A) receptor-mediated 30-100 Hz gamma oscillations underlie some aspects of the hyperthermic population spike activity. In 24 rat hippocampal slices, the hyperthermic population spike activity occurred at an average frequency of 45.9 +/- 14.9 Hz (Mean +/- SE, range = 21-79 Hz, n = 24), which does not differ significantly from the frequency of post-tetanic gamma oscillations (47.1 +/- 14.9 Hz, n = 34) in the same system. High intensity tetanic stimulation induces hippocampal neuronal discharges followed by a slow SD that has the magnitude and time course of the SD, which resembles hyperthermic responses. Both post-tetanic gamma oscillations and hyperthermic population spike activity can be blocked completely by a specific GABA(A) receptor blocker, bicuculline (5-20 microM). Bath-apply kynurenic acid (7 mM) blocks synaptic transmission, but fails to prevent hyperthermic population spikes, while intracellular diffusion of QX-314 (30 mM) abolishes spikes and produces a smooth depolarization in intracellular recording.
conclusionThese results suggest that the GABA(A) receptor-governed gamma oscillations underlie the hyperthermic population spike activity in immature hippocampal slices.
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