ArticleJournal of cellular biochemistry2001
Trichostatin A inhibits beta-casein expression in mammary epithelial cells.
Article in Journal of cellular biochemistry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Laminin Modulates the Stem Cell Population in LM05-E Murine Breast Cancer Cells through the Activation of the MAPK/ERK Pathway.Cancer research and treatment · 2017Article
- Effects of Trichostatin A on Cumulus Expansion during Mouse Oocyte Maturation.Asian-Australasian journal of animal sciences · 2013Article
- Growth of lung cancer cells in three-dimensional microenvironments reveals key features of tumor malignancy.Integrative biology : quantitative biosciences from nano to macro · 2012Article
- Epigenetic regulation of milk production in dairy cows.Journal of mammary gland biology and neoplasia · 2010Review
- Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis.Modern rheumatology · 2010Article
- Adipose-depleted mammary epithelial cells and organoids.Journal of mammary gland biology and neoplasia · 2009Article
- Contributions of extracellular matrix signaling and tissue architecture to nuclear mechanisms and spatial organization of gene expression control.Biochimica et biophysica acta · 2009Review
- Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia.The EMBO journal · 2008Article
- Cell shape regulates global histone acetylation in human mammary epithelial cells.Experimental cell research · 2007Article
- Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors.The Journal of biological chemistry · 2007Article
- Extracellular matrix, nuclear and chromatin structure, and gene expression in normal tissues and malignant tumors: a work in progress.Advances in cancer research · 2007Review
- Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer.Annual review of cell and developmental biology · 2006Review
- Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation.Seminars in cancer biology · 2005Review
- Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption.Arthritis research & therapy · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Many aspects of cellular behavior are defined by the content of information provided by association of the extracellular matrix (ECM) and with cell membrane receptors. When cultured in the presence of laminin-containing ECM and prolactin (Prl), normal mammary epithelial cells express the milk protein beta-casein. We have previously found that the minimal ECM- and Prl-responsive enhancer element BCE-1 was only active when stably integrated into chromatin, and that trichostatin A (TSA), a reagent that leads to alterations in chromatin structure, was able to activate the integrated enhancer element. We now show that endogenous beta-casein gene, which is controlled by a genetic assembly that is highly similar to that of BCE-1 and which is also activated by incubation in ECM and Prl, is instead inhibited by TSA. We provide evidence that the differing response of beta-casein and BCE-1 to TSA is neither due to an unusual effect of TSA on mammary epithelial cells, nor to secondary consequences from the expression of a separate gene, nor to a particular property of the BCE-1 construct. As a component of this investigation, we also showed that ECM mediated rapid histone deacetylation in mammary epithelial cells. These results are discussed in combination with previous work showing that TSA mediates the differentiation of many types of cancer cells but inhibits differentiation of some nonmalignant cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.