Evidence map›Paper›PMID 11744505›Full record

ReviewEnvironmental health perspectives2001

Environmental contaminants as etiologic factors for diabetes.

M P Longnecker, J L Daniels

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Environmental health perspectives, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 5 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 5 syntheses or guidelines pooled it, 223 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Knowns and unknowns on burden of disease due to chemicals: a systematic review.Environmental health : a global access science source · 2011
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Critical Overview on Endocrine Disruptors in Diabetes Mellitus.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Review
  13. Targeting Glycoproteins as a therapeutic strategy for diabetes mellitus and its complications.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. No evidence of the role of early chemical exposure in the development of β-cell autoimmunity.Environmental science and pollution research international · 2019
    Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

M P LongneckerEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709-2233, USA. longnecker@niehs.nih.gov
J L Daniels
National Institute of Environmental Health Sciences · US

Funding

Human Health Effects Of Exposure To Organochlorine CompoundsZIAES049016 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONGNECKER, MATTHEW · 2009 to 2015
$1.0M
HUMAN HEALTH EFFECTS OF EXPOSURE TO ORGANOCHLORINE COMPOUNDSZ01ES049016 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONGNECKER, MATTHEW P · 1996 to 2008
$95k
6 · The paper itself

Abstract

For both type 1 and type 2 diabetes mellitus, the rates have been increasing in the United States and elsewhere; rates vary widely by country, and genetic factors account for less than half of new cases. These observations suggest environmental factors cause both type 1 and type 2 diabetes. Occupational exposures have been associated with increased risk of diabetes. In addition, recent data suggest that toxic substances in the environment, other than infectious agents or exposures that stimulate an immune response, are associated with the occurrence of these diseases. We reviewed the epidemiologic data that addressed whether environmental contaminants might cause type 1 or type 2 diabetes. For type 1 diabetes, higher intake of nitrates, nitrites, and N-nitroso compounds, as well as higher serum levels of polychlorinated biphenyls have been associated with increased risk. Overall, however, the data were limited or inconsistent. With respect to type 2 diabetes, data on arsenic and 2,3,7,8-tetrachlorodibenzo-p-dioxin relative to risk were suggestive of a direct association but were inconclusive. The occupational data suggested that more data on exposure to N-nitroso compounds, arsenic, dioxins, talc, and straight oil machining fluids in relation to diabetes would be useful. Although environmental factors other than contaminants may account for the majority of type 1 and type 2 diabetes, the etiologic role of several contaminants and occupational exposures deserves further study.

Indexed as

Occupational ExposureDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Environmental PollutantsEpidemiologic StudiesHumansPolychlorinated BiphenylsRisk FactorsEnvironmental PollutantsPolychlorinated Biphenyls

Identifiers

PMID11744505
PMCPMC1240622
OpenAlexW2082452703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.