ArticleEMBO reports2001
The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic.
Article in EMBO reports, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 78 citations in OpenAlex.
- Organelle abnormalities in Alzheimer's disease.Organelle (Tucson, Ariz.) · 2025Article
- CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation.Cancer medicine · 2021Article
- Septins in Stem Cells.Frontiers in cell and developmental biology · 2021Review
- Syntaxin-1/TI-VAMP SNAREs interact with Trk receptors and are required for neurotrophin-dependent outgrowth.Oncotarget · 2018Article
- Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Cdk5 Is Essential for Amphetamine to Increase Dendritic Spine Density in Hippocampal Pyramidal Neurons.Frontiers in cellular neuroscience · 2017Article
- Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Acute and chronic stress differentially regulate cyclin-dependent kinase 5 in mouse brain: implications to glucocorticoid actions and major depression.Translational psychiatry · 2015Article
- Golgi fragmentation in Alzheimer's disease.Frontiers in neuroscience · 2015Review
- LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Components of the CtBP1/BARS-dependent fission machinery.Histochemistry and cell biology · 2013Review
- Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology.Brain disorders & therapy · 2012Article
- A 14-3-3γ dimer-based scaffold bridges CtBP1-S/BARS to PI(4)KIIIβ to regulate post-Golgi carrier formation.Nature cell biology · 2012Article
- The Golgi in cell migration: regulation by signal transduction and its implications for cancer cell metastasis.TheScientificWorldJournal · 2012Review
- A signaling mechanism coupling netrin-1/deleted in colorectal cancer chemoattraction to SNARE-mediated exocytosis in axonal growth cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein.Cellular and molecular life sciences : CMLS · 2011Article
- The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration.PloS one · 2011Article
- Article
- Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.The Journal of cell biology · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We show here that an active Cdk5-p35 kinase is present in Golgi membranes, where it associates with a detergent-insoluble fraction containing actin. In addition, Cdk5-p35-dependent phosphorylation of alpha-PAK immunoreactive protein species was detected in Golgi membranes, as well as an interaction with the small GTPase, Cdc42. Moreover, antisense oligonucleotide suppression of Cdk5 or p35 in young cultured neurons, as well as inhibition of Cdk5 activity with olomoucine, blocks the formation of membrane vesicles from the Golgi apparatus. Taken together, these results show a novel subcellular localization of this kinase and suggest a role for Cdk5-p35 in membrane traffic during neuronal process outgrowth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.