ArticleBritish journal of cancer2001
Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells.
Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 118 citations in OpenAlex.
- Mechanistic Approach into 1,2,3-triazoles-based IIIM(S)-RS98 Mediated Apoptosis in Lung Cancer Cells.The AAPS journal · 2025Article
- Review
- Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology.Biomolecules · 2020Review
- A unified structural model of the mammalian translocator protein (TSPO).Journal of biomolecular NMR · 2019Article
- Reduction of Traumatic Brain Damage by Tspo Ligand Etifoxine.International journal of molecular sciences · 2019Article
- Evaluation of TSPO PET Ligands [Molecular imaging and biology · 2017Article
- Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening.Bioconjugate chemistry · 2017Article
- The Prognostic Value of Peripheral Benzodiazepine Receptor in Patients with Esophageal Squamous Cell Carcinoma.Journal of Cancer · 2017Article
- Prognostic role of translocator protein and oxidative stress markers in chronic lymphocytic leukemia patients treated with bendamustine plus rituximab.Oncology letters · 2015Article
- P2X and P2Y receptors—role in the pathophysiology of the nervous system.International journal of molecular sciences · 2014Review
- Preclinical imaging evaluation of novel TSPO-PET ligand 2-(5,7-Diethyl-2-(4-(2-[(18)F]fluoroethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide ([ (18)F]VUIIS1008) in glioma.Molecular imaging and biology · 2014Article
- The 18 kDa translocator protein, microglia and neuroinflammation.Brain pathology (Zurich, Switzerland) · 2014Review
- The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death.Frontiers in oncology · 2014Review
- The 1,4-benzodiazepine Ro5-4864 (4-chlorodiazepam) suppresses multiple pro-inflammatory mast cell effector functions.Cell communication and signaling : CCS · 2013Article
- Developmental expression of translocator protein/peripheral benzodiazepine receptor in reproductive tissues.PloS one · 2013Article
- A translocator protein ligand PK11195 shows antigrowth activity in human choriocarcinoma cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress.The Journal of endocrinology · 2012Article
- Quantitative preclinical imaging of TSPO expression in glioma using N,N-diethyl-2-(2-(4-(2-18F-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2012Article
- Functional characterization of the human translocator protein (18kDa) gene promoter in human breast cancer cell lines.Biochimica et biophysica acta · 2012Article
- TSPO 18 kDa (PBR) Targeted Photosensitizers for Cancer Imaging (PET) and PDT.ACS medicinal chemistry letters · 2011Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The peripheral benzodiazepine receptor (PBR) has been implicated in growth control of various tumour models. Although colorectal cancers were found to overexpress PBR, the functional role of PBR in colorectal cancer growth has not been addressed to date. Using primary cell cultures of human colorectal cancers and the human colorectal carcinoma cell lines HT29, LS174T, and Colo320 DM we studied the involvement of PBR in the growth control and apoptosis of colorectal cancers. Both mRNA and protein expression of PBR were detected by RT-PCR and flow cytometry. Using confocal laser scanning microscopy and immunohistochemistry the PBR was localized in the mitochondria. The specific PBR ligands FGIN-1-27, PK 11195, or Ro5-4864 inhibited cell proliferation dose-dependently. FGIN-1-27 decreased the mitochondrial membrane potential, which indicates an early event in apoptosis. Furthermore, FGIN-1-27, PK 11195 or Ro5-4864 increased caspase-3 activity. In addition to their apoptosis-inducing effects, PBR ligands induced cell cycle arrest in the G(1)/G(0)-phase. Thus, our data demonstrate a functional involvement of PBR in colorectal cancer growth and qualify the PBR as a possible target for innovative therapeutic approaches in colorectal cancer.
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