ArticleAmerican journal of human genetics2002
A genomewide search for type 2 diabetes-susceptibility genes in indigenous Australians.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- African-Americans and Indigenous Peoples Have Increased Burden of Diseases of the Exocrine Pancreas: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2019Pooled it
- Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.Journal of diabetes research · 2015Pooled it
- Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies.Cardiovascular diabetology · 2012Pooled it
- Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium.Human heredity · 2008Pooled it
- Genetics, adaptation to environmental changes and archaic admixture in the pathogenesis of diabetes mellitus in Indigenous Australians.Reviews in endocrine & metabolic disorders · 2019Review
- Pregnancy risk factors associated with birthweight of infants born to Australian Aboriginal women in an urban setting - a retrospective cohort study.BMC pregnancy and childbirth · 2018Article
- The recurrence risk of genetic complex diseases.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Review
- ABCC5 transporter is a novel type 2 diabetes susceptibility gene in European and African American populations.Annals of human genetics · 2014Article
- Progressive resistance training in polycystic ovary syndrome: can pumping iron improve clinical outcomes?Sports medicine (Auckland, N.Z.) · 2014Review
- Combined genome-wide linkage and association analyses of fasting glucose level in healthy twins and families of Korea.Journal of Korean medical science · 2013Article
- Association of TRPC1 gene polymorphisms with type 2 diabetes and diabetic nephropathy in Han Chinese population.Endocrine research · 2013Article
- Agreement among type 2 diabetes linkage studies but a poor correlation with results from genome-wide association studies.Diabetologia · 2009Article
- Candidate genes for plasma triglyceride, FFA, and glucose revealed from an intercross between inbred mouse strains NZB/B1NJ and NZW/LacJ.Journal of lipid research · 2008Article
- Rapid increases in obesity in Jamaica, compared to Nigeria and the United States.BMC public health · 2008Article
- Article
- The Genetic Basis of Type 2 Diabetes.Cellscience · 2006Article
- Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes.Nucleic acids research · 2006Article
- Toward health and wellbeing for indigenous Australians.Postgraduate medical journal · 2005Article
- [Genetics of type 2 diabetes].Der Internist · 2005Review
- An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese.Journal of molecular medicine (Berlin, Germany) · 2005Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of type 2 diabetes among Australian residents is 7.5%; however, prevalence rates up to six times higher have been reported for indigenous Australian communities. Epidemiological evidence implicates genetic factors in the susceptibility of indigenous Australians to type 2 diabetes and supports the hypothesis of the "thrifty genotype," but, to date, the nature of the genetic predisposition is unknown. We have ascertained clinical details from a community of indigenous Australian descent in North Stradbroke Island, Queensland. In this population, the phenotype is characterized by severe insulin resistance. We have conducted a genomewide scan, at an average resolution of 10 cM, for type 2 diabetes-susceptibility genes in a large multigeneration pedigree from this community. Parametric linkage analysis undertaken using FASTLINK version 4.1p yielded a maximum two-point LOD score of +2.97 at marker D2S2345. Multipoint analysis yielded a peak LOD score of +3.9 <1 cM from marker D2S2345, with an 18-cM 3-LOD support interval. Secondary peak LOD scores were noted on chromosome 3 (+1.8 at recombination fraction [theta] 0.05, at marker D3S1311) and chromosome 8 (+1.77 at theta=0.0, at marker D8S549). These chromosomal regions are likely to harbor novel susceptibility genes for type 2 diabetes in the indigenous Australian population.
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