Evidence map›Paper›PMID 11742409›Full record

ReviewNature2001

Global and societal implications of the diabetes epidemic.

P Zimmet, K G Alberti, J Shaw

5 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 1,654 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,654citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01589445 phase4completedstarted 2008, after this paper: background citation

Modulation of Insulin Secretion and Insulin Sensitivity in Bangladeshi Type 2 Diabetic Subjects by an Insulin Sensitizer Pioglitazone and T2DM Association With PPARG Gene Polymorphism.

Ran2008Enrolled77Registered outcomes6Posted comparisons11ConditionsType 2 Diabetes MellitusArmsMetformin hydrochloride, pioglitazone hydrochloride
Open the trial in the graph
NCT05343767 nacompletedstarted 2018, after this paper: background citation

A Phase II, Randomized, Double Blind, Double Dummy, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of Low-Glu in Patients Newly Diagnosed With Type II Diabetes Mellitus

Ran2018Enrolled198Registered outcomes6Posted comparisons0ConditionsType2 Diabetes MellitusArmsMetformin, Natural Wellness Low-Glu high dose, Natural Wellness Low-Glu low dose
Open the trial in the graph
NCT02074423 nacompletednot on this mapstarted 2013, after this paper: background citation

A Randomized, Controlled, Double-blind, Cross-over Clinical Trial, Evaluating the Effect of MealShape™ on the Postprandial Glycemia After Eating Standard Food, in Healthy Volunteers.

TypeinterventionalSponsorDialphaRan2013 to 2014Enrolled18ConditionsPostprandial Glycemia, Postprandial InsulinemiaArmsMealShape cinnamon extract, Placebo
NCT03165812 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Single Anastomosis Duodeno Jejunal Bypass With Sleeve Gastrectomy (SADJB-SG) Versus Intensive Medical Therapy (IMT) in the Treatment of Type 2 Diabetes Mellitus Among Asian Patients With BMI 23.5 - 30 kg/m2: A Clinical Trial

TypeinterventionalSponsorUniversiti Putra MalaysiaRan2017 to 2019Enrolled84ConditionsDiabetes Mellitus, Type 2, OverweightArmsSADJB-SG group, IMT group
NCT06729008 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Diabetes-Specific Nutrition Formula on the Metabolic Parameters of Filipino Adults with Metabolic Syndrome: a Randomized Crossover Trial

TypeinterventionalSponsorSt. Luke's Medical Center, PhilippinesRan2025 to 2025Enrolled35ConditionsMetabolic SyndromeArmsDiabetes-specific nutrition formula (DSNF), Medical Nutrition Therapy
3 · Its place in the literature

Who cites it

1,654 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Article
  10. Trajectory of Kidney Function in T1D over Time: A Scoping Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

1,594 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

P ZimmetInternational Diabetes Institute, 260 Kooyong Road, Caulfield, Victoria 3162, Australia. pzimmet@idi.org.au
K G Alberti
J Shaw

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in human behaviour and lifestyle over the last century have resulted in a dramatic increase in the incidence of diabetes worldwide. The epidemic is chiefly of type 2 diabetes and also the associated conditions known as 'diabesity' and 'metabolic syndrome'. In conjunction with genetic susceptibility, particularly in certain ethnic groups, type 2 diabetes is brought on by environmental and behavioural factors such as a sedentary lifestyle, overly rich nutrition and obesity. The prevention of diabetes and control of its micro- and macrovascular complications will require an integrated, international approach if we are to see significant reduction in the huge premature morbidity and mortality it causes.

Indexed as

Disease OutbreaksAdolescentAdultAnimalsChildDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2ForecastingGlobal HealthGlucose IntoleranceHumansMetabolic SyndromePrevalenceSociology

Identifiers

PMID11742409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.