ArticleProceedings of the National Academy of Sciences of the United States of America2001
Quantification of intrinsic residual viral replication in treated HIV-infected patients.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Article
- A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients.PLoS computational biology · 2011Article
- Modeling HIV persistence, the latent reservoir, and viral blips.Journal of theoretical biology · 2009Review
- Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips.Mathematical biosciences · 2009Article
- Transient viremia, plasma viral load, and reservoir replenishment in HIV-infected patients on antiretroviral therapy.Journal of acquired immune deficiency syndromes (1999) · 2007Article
- HIV recombination: what is the impact on antiretroviral therapy?Journal of the Royal Society, Interface · 2005Article
- Adherence to antiretroviral therapy and its impact on clinical outcome in HIV-infected patients.Journal of the Royal Society, Interface · 2005Article
- Dynamics of HIV-1 recombination in its natural target cells.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The macrophage response to HIV-1: Intracellular control of X4 virus replication accompanied by activation of chemokine and cytokine synthesis.Journal of neurovirology · 2002Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The intrinsic rate of viral replication in HIV-infected patients treated with antiretroviral combination therapy is estimated by using a mathematical model of viral dynamics. This intrinsic replication is found to be episodic, varying considerably in quantity between patients (even among those achieving long-term undetectable levels of viremia) and is always reduced by increasing the potency of the antiviral drug regimen. The analysis reveals that even in conditions of perfect patient adherence and drug penetration a substantial level of residual viral replication is expected. The rate of evolution in the viral quasispecies, and thus also the probability of new drug-resistant viral strains being created, is proportional to the total amount of residual viral replication. Under most circumstances, the viral population continues to turn over rapidly during therapy, albeit at a much reduced level.
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Registered trials
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