ArticleJournal of bacteriology2002
Overexpression of the PepF oligopeptidase inhibits sporulation initiation in Bacillus subtilis.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Influence of PepF peptidase and sporulation on microcin J25 production inMicrobiology spectrum · 2024Article
- Strategies of chemolithoautotrophs adapting to high temperature and extremely acidic conditions in a shallow hydrothermal ecosystem.Microbiome · 2023Article
- Proteomic Characterization of Virulence Factors and Related Proteins inInternational journal of molecular sciences · 2022Article
- Competence shut-off by intracellular pheromone degradation in salivarius streptococci.PLoS genetics · 2022Article
- MsmR1, a global transcription factor, regulates polymyxin synthesis and carbohydrate metabolism inFrontiers in microbiology · 2022Article
- Analyses of competent and non-competent subpopulations of Bacillus subtilis reveal yhfW, yhxC and ncRNAs as novel players in competence.Environmental microbiology · 2020Article
- Ratiometric population sensing by a pump-probe signaling system in Bacillus subtilis.Nature communications · 2020Article
- Article
- Analysis of Spo0M function in Bacillus subtilis.PloS one · 2017Article
- Intrahost Evolution of Methicillin-Resistant Staphylococcus aureus USA300 Among Individuals With Reoccurring Skin and Soft-Tissue Infections.The Journal of infectious diseases · 2016Article
- Identification and Characterization of anFrontiers in microbiology · 2016Article
- Genomic, Transcriptomic and Metabolomic Studies of Two Well-Characterized, Laboratory-Derived Vancomycin-Intermediate Staphylococcus aureus Strains Derived from the Same Parent Strain.Antibiotics (Basel, Switzerland) · 2015Article
- The fusidic acid stimulon of Staphylococcus aureus.The Journal of antimicrobial chemotherapy · 2008Article
- Role of bacterial peptidase F inferred by statistical analysis and further experimental validation.HFSP journal · 2008Article
- Essential bacterial functions encoded by gene pairs.Journal of bacteriology · 2007Article
- Characterization of a novel PepF-like oligopeptidase secreted by Bacillus amyloliquefaciens 23-7A.Applied and environmental microbiology · 2006Article
- Proteomic signature of Lactococcus lactis NCDO763 cultivated in milk.Applied and environmental microbiology · 2005Article
- The Bacillus subtilis SinR and RapA developmental regulators are responsible for inhibition of spore development by alcohol.Journal of bacteriology · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The yjbG gene encoding the homologue of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis (Monnet et al., J. Biol. Chem. 269:32070-32076, 1994; Nardi et al., J. Bacteriol. 179:4164-4171, 1997) has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when present in the cells on a multicopy plasmid. Genetic analysis suggested that the inhibitory effect is due to hydrolysis of the PhrA peptide in a form as small as the pentapeptide (ARNQT). Inactivation of PhrA results in deregulation of the RapA phosphatase and thus dephosphorylation of the Spo0F approximately P response regulator component of the phosphorelay for sporulation initiation. When overexpressed, the B. subtilis PepF is most likely hydrolyzing additional peptides of the Phr family, as is the case for PhrC involved in control of competence development. Chromosomal inactivation of the yjbG/pepF gene did not give rise to any detectable phenotype. The function of PepF in B. subtilis remains unknown. Limited experiments with a yjbG paralogue called yusX indicated that a frameshift is present, making the corresponding gene product inactive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.