ArticleAAPS pharmSci2000
Human membrane transporter database: a Web-accessible relational database for drug transport studies and pharmacogenomics.
Article in AAPS pharmSci, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 50 citations in OpenAlex.
- Metrabase: a cheminformatics and bioinformatics database for small molecule transporter data analysis and (Q)SAR modeling.Journal of cheminformatics · 2015Article
- Human transporter database: comprehensive knowledge and discovery tools in the human transporter genes.PloS one · 2014Article
- Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions.Molecular systems biology · 2010Article
- Timing and Duration of Drug Exposure Affects Outcomes of a Drug-Nutrient Interaction During Ontogeny.Pharmaceutics · 2010Article
- Computational reconstruction of tissue-specific metabolic models: application to human liver metabolism.Molecular systems biology · 2010Article
- GATMD: γ-aminobutyric acid transporter mutagenesis database.Database : the journal of biological databases and curation · 2010Article
- Prediction of functional class of proteins and peptides irrespective of sequence homology by support vector machines.Bioinformatics and biology insights · 2009Article
- Fish drug analysis--Phish-Pharm: a searchable database of pharmacokinetics data in fish.The AAPS journal · 2005Review
- Transporter database, TP-Search: a web-accessible comprehensive database for research in pharmacokinetics of drugs.Pharmaceutical research · 2004Article
- What do we mean by Internet access? A framework for health researchers.Preventing chronic disease · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human genome contains numerous genes that encode membrane transporters and related proteins. For drug discovery, development, and targeting, one needs to know which transporters play a role in drug disposition and effects. Moreover, genetic polymorphisms in human membrane transporters may contribute to interindividual differences in the response to drugs. Pharmacogenetics, and, on a genome-wide basis, pharmacogenomics, address the effect of genetic variants on an individual's response to drugs and xenobiotics. However, our knowledge of the relevant transporters is limited at present. To facilitate the study of drug transporters on a broad scale, including the use of microarray technology, we have constructed a human membrane transporter database (HMTD). Even though it is still largely incomplete, the database contains information on more than 250 human membrane transporters, such as sequence, gene family, structure, function, substrate, tissue distribution, and genetic disorders associated with transporter polymorphisms. Readers are invited to submit additional data. Implemented as a relational database, HMTD supports complex biological queries. Accessible through a Web browser user interface via Common Gateway Interface (CGI) and Java Database Connection (JDBC), HMTD also provides useful links and references, allowing interactive searching and downloading of data. Taking advantage of the features of an electronic journal, this paper serves as an interactive tutorial for using the database, which we expect to develop into a research tool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.