ArticleAAPS pharmSci2000
Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics.
Article in AAPS pharmSci, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 64 citations in OpenAlex.
- Oligopeptide/Histidine Transporter PHT1 and PHT2 - Function, Regulation, and Pathophysiological Implications Specifically in Immunoregulation.Pharmaceutical research · 2023Review
- Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1.Nature communications · 2023Article
- Expression dynamics of solute carrier family 15 member 4 (SLC15A4) and its potential regulatory role in ovarian development of the Indian white shrimp, Penaeus indicus.Molecular biology reports · 2020Article
- Multiple Drug Transporters Contribute to the Placental Transfer of Emtricitabine.Antimicrobial agents and chemotherapy · 2019Article
- Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Article
- Functional Characterization of Human Peptide/Histidine Transporter 1 in Stably Transfected MDCK Cells.Molecular pharmaceutics · 2018Article
- The Concise Guide to PHARMACOLOGY 2013/14: transporters.British journal of pharmacology · 2013Article
- Gene expression of carnosine-related enzymes and transporters in skeletal muscle.European journal of applied physiology · 2013Article
- Expression Profile of Drug and Nutrient Absorption Related Genes in Madin-Darby Canine Kidney (MDCK) Cells Grown under Differentiation Conditions.Pharmaceutics · 2012Article
- THE EVALUATION OF PEPTIDE/HISTIDINE TRANSPORTER 1 (PHT1) FUNCTION: UPTAKE KINETICS UTILIZING A COS-7 STABLY TRANSFECTED CELL LINE.Revista mexicana de ciencias farmaceutica · 2011Article
- The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics.British journal of pharmacology · 2010Article
- Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity.Drug metabolism and pharmacokinetics · 2008Review
- Phenotype analysis of mice deficient in the peptide transporter PEPT2 in response to alterations in dietary protein intake.Pflugers Archiv : European journal of physiology · 2006Article
- The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology.Pflugers Archiv : European journal of physiology · 2004Review
- Preliminary investigation into the expression of proton-coupled oligopeptide transporters in neural retina and retinal pigment epithelium (RPE): lack of functional activity in RPE plasma membranes.Pharmaceutical research · 2003Article
- Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney.Molecular and cellular biology · 2003Article
- A semiautomated approach to gene discovery through expressed sequence tag data mining: discovery of new human transporter genes.AAPS pharmSci · 2003Article
- Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 in vitro cell culture model, and multiple human tissues.AAPS pharmSci · 2001Article
- Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH-sensing regulatory splice variant.AAPS pharmSci · 2001Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proton-dependent oligopeptide transporters (POT) gene family currently consists of approximately 70 cloned cDNAs derived from diverse organisms. In mammals, two genes encoding peptide transporters, PepT1 and PepT2 have been cloned in several species including humans, in addition to a rat histidine/peptide transporter (rPHT1). Because the Candida elegans genome contains five putative POT genes, we searched the available protein and nucleic acid databases for additional mammalian/human POT genes, using iterative BLAST runs and the human expressed sequence tags (EST) database. The apparent human orthologue of rPHT1 (expression largely confined to rat brain and retina) was represented by numerous ESTs originating from many tissues. Assembly of these ESTs resulted in a contiguous sequence covering approximately 95% of the suspected coding region. The contig sequences and analyses revealed the presence of several possible splice variants of hPHT1. A second closely related human EST-contig displayed high identity to a recently cloned mouse cDNA encoding cyclic adenosine monophosphate (cAMP)-inducible 1 protein (gi:4580995). This contig served to identify a PAC clone containing deduced exons and introns of the likely human orthologue (termed hPHT2). Northern analyses with EST clones indicated that hPHT1 is primarily expressed in skeletal muscle and spleen, whereas hPHT2 is found in spleen, placenta, lung, leukocytes, and heart. These results suggest considerable complexity of the human POT gene family, with relevance to the absorption and distribution of cephalosporins and other peptoid drugs.
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