ArticleMolecular biology of the cell2001
Dynamic behavior of microtubules during dynein-dependent nuclear migrations of meiotic prophase in fission yeast.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Integrative modeling of the genome structure and dynamics in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A force balance model for a cell size-dependent meiotic nuclear oscillation in fission yeast.EMBO reports · 2023Article
- The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing.Frontiers in cell and developmental biology · 2023Review
- Review
- A conserved mechanism for mitochondria-dependent dynein anchoring.Molecular biology of the cell · 2019Article
- Position matters: multiple functions of LINC-dependent chromosome positioning during meiosis.Current genetics · 2017Article
- Moving and stopping: Regulation of chromosome movement to promote meiotic chromosome pairing and synapsis.Nucleus (Austin, Tex.) · 2017Review
- Article
- Fission yeast myosin I facilitates PI(4,5)PProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Understanding force-generating microtubule systems through in vitro reconstitution.Cell adhesion & migration · 2016Review
- Identification and Analysis ofFrontiers in plant science · 2016Article
- Microtubule minus end motors kinesin-14 and dynein drive nuclear congression in parallel pathways.The Journal of cell biology · 2015Article
- Gathering up meiotic telomeres: a novel function of the microtubule-organizing center.Cellular and molecular life sciences : CMLS · 2014Review
- End-on microtubule-dynein interactions and pulling-based positioning of microtubule organizing centers.Cell cycle (Georgetown, Tex.) · 2012Review
- Article
- Chiasmata promote monopolar attachment of sister chromatids and their co-segregation toward the proper pole during meiosis I.PLoS genetics · 2011Article
- Coordinating mitosis with cell polarity: Molecular motors at the cell cortex.Seminars in cell & developmental biology · 2010Review
- Dancing genomes: fungal nuclear positioning.Nature reviews. Microbiology · 2009Review
- Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsis.Cell · 2009Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During meiotic prophase in fission yeast, the nucleus migrates back and forth between the two ends of the cell, led by the spindle pole body (SPB). This nuclear oscillation is dependent on astral microtubules radiating from the SPB and a microtubule motor, cytoplasmic dynein. Here we have examined the dynamic behavior of astral microtubules labeled with the green fluorescent protein during meiotic prophase with the use of optical sectioning microscopy. During nuclear migrations, the SPB mostly follows the microtubules that extend toward the cell cortex. SPB migrations start when these microtubules interact with the cortex and stop when they disappear, suggesting that these microtubules drive nuclear migrations. The microtubules that are followed by the SPB often slide along the cortex and are shortened by disassembly at their ends proximal to the cortex. In dynein-mutant cells, where nuclear oscillations are absent, the SPB never migrates by following microtubules, and microtubule assembly/disassembly dynamics is significantly altered. Based on these observations, together with the frequent accumulation of dynein at a cortical site where the directing microtubules interact, we propose a model in which dynein drives nuclear oscillation by mediating cortical microtubule interactions and regulating the dynamics of microtubule disassembly at the cortex.
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