ArticleMolecular biology of the cell2001
Structure-function analysis of fission yeast Hus1-Rad1-Rad9 checkpoint complex.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Population genomics provides insights into the genetic basis of adaptive evolution in the mushroom-forming fungusJournal of advanced research · 2022Article
- Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions.The Journal of biological chemistry · 2015Article
- Processivity factor of DNA polymerase and its expanding role in normal and translesion DNA synthesis.Biochimica et biophysica acta · 2010Review
- Article
- Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.Science (New York, N.Y.) · 2008Article
- Localization of hRad9 in breast cancer.BMC cancer · 2008Article
- The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair.Nucleic acids research · 2007Article
- Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.Molecular and cellular biology · 2005Article
- Review
- Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects.Oncogene · 2004Article
- Article
- Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells.Molecular and cellular biology · 2004Article
- The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair.Nucleic acids research · 2004Article
- Genomic instability and endoreduplication triggered by RAD17 deletion.Genes & development · 2003Article
- Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process.Protein science : a publication of the Protein Society · 2002Article
- Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.Genetics · 2002Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Hus1, Rad1, and Rad9 are three evolutionarily conserved proteins required for checkpoint control in fission yeast. These proteins are known to form a stable complex in vivo. Recently, computational studies have predicted structural similarity between the individual proteins of Hus1-Rad1-Rad9 complex and the replication processivity factor proliferating cell nuclear antigen (PCNA). This has led to the proposal that the Hus1-Rad1-Rad9 complex may form a PCNA-like ring structure, and could function as a sliding clamp during checkpoint control. In the present study, we have attempted to test the predictions of this model by asking whether the PCNA alignment identifies functionally important residues or explains mutant phenotypes of hus1, rad1, or rad9 alleles. Although some of our results are consistent with the PCNA alignment, others indicate that the Hus1-Rad1-Rad9 complex possesses unique structural and functional features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.