ArticleMolecular and cellular biology2002
Yeast hnRNP K-like genes are involved in regulation of the telomeric position effect and telomere length.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
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- Increased copper bioremediation ability of new transgenic and adapted Saccharomyces cerevisiae strains.Environmental science and pollution research international · 2016Article
- The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.Microbiology and molecular biology reviews : MMBR · 2016Review
- hnRNP K coordinates transcriptional silencing by SETDB1 in embryonic stem cells.PLoS genetics · 2015Article
- Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis.The Journal of biological chemistry · 2013Article
- Coming into view: eukaryotic iron chaperones and intracellular iron delivery.The Journal of biological chemistry · 2012Review
- RNA-binding protein Khd1 and Ccr4 deadenylase play overlapping roles in the cell wall integrity pathway in Saccharomyces cerevisiae.Eukaryotic cell · 2011Article
- Distinct roles for Khd1p in the localization and expression of bud-localized mRNAs in yeast.RNA (New York, N.Y.) · 2008Article
- Epistatic interaction between the K-homology domain protein HEK2 and SIR1 at HMR and telomeres in yeast.Journal of molecular biology · 2008Article
- A statistical method to incorporate biological knowledge for generating testable novel gene regulatory interactions from microarray experiments.BMC bioinformatics · 2007Article
- Fast chromatin immunoprecipitation assay.Nucleic acids research · 2006Article
- Heterogeneous nuclear ribonucleoprotein K represses transcription from a cytosine/thymidine-rich element in the osteocalcin promoter.The Biochemical journal · 2005Article
- hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere.Nucleic acids research · 2005Article
- Nuclear shift of hnRNP K protein in neoplasms and other states of enhanced cell proliferation.British journal of cancer · 2003Article
- Transient recruitment of the hnRNP K protein to inducibly transcribed gene loci.Nucleic acids research · 2003Article
- Distinct domains in the CArG-box binding factor A destabilize tetraplex forms of the fragile X expanded sequence d(CGG)n.Nucleic acids research · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mammalian heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA- and DNA-binding protein implicated in the regulation of gene expression processes. To better understand its function, we studied two Saccharomyces cerevisiae homologues of the human hnRNP K, PBP2 and HEK2 (heterogeneous nuclear RNP K-like gene). pbp2Delta and hek2Delta mutations inhibited expression of a marker gene that was inserted near telomere but not at internal chromosomal locations. The telomere proximal to the ectopic marker gene became longer, while most of the other telomeres were not altered in the double mutant cells. We provide evidence that telomere elongation might be the primary event that causes enhanced silencing of an adjacent reporter gene. The telomere lengthening could, in part, be explained by the inhibitory effect of hek2Delta mutation on the telomeric rapid deletion pathway. Hek2p was detected in a complex with chromosome regions proximal to the affected telomere, suggesting a direct involvement of this protein in telomere maintenance. These results identify a role for hnRNP K-like genes in the structural and functional organization of telomeric chromatin in yeast.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.