ArticleMolecular and cellular biology2002
Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 111 citations in OpenAlex.
- Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton.Communications biology · 2026Article
- The E2F family: a ray of dawn in cardiomyopathy.Molecular and cellular biochemistry · 2025Review
- DLGAP5 triggers proliferation and metastasis of bladder cancer by stabilizing E2F1 via USP11.Oncogene · 2024Article
- MiR-497-5p down-regulates CDCA4 to restrains lung squamous cell carcinoma progression.Journal of cardiothoracic surgery · 2021Article
- Comparison of anadromous and landlocked Atlantic salmon genomes reveals signatures of parallel and relaxed selection across the Northern Hemisphere.Evolutionary applications · 2021Article
- Core cell cycle machinery is crucially involved in both life and death of post-mitotic neurons.Cellular and molecular life sciences : CMLS · 2020Review
- Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin.Trends in cell biology · 2020Review
- E2F1 mediates the downregulation of POLD1 in replicative senescence.Cellular and molecular life sciences : CMLS · 2019Article
- Knockdown of cell division cycle-associated protein 4 expression inhibits proliferation of triple negative breast cancer MDA-MB-231 cellsOncology letters · 2019Article
- Dual function of MDM2 and MDMX toward the tumor suppressors p53 and RB.Genes & cancer · 2016Review
- Survivin: A molecular biomarker in cancer.The Indian journal of medical research · 2015Review
- Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis.Scientific reports · 2013Article
- Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin.Journal of cellular and molecular medicine · 2010Article
- p53 and E2f: partners in life and death.Nature reviews. Cancer · 2009Review
- Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways.Molecular biology of the cell · 2009Article
- E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1.Molecular biology of the cell · 2008Article
- E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage.PLoS genetics · 2008Article
- Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.Developmental cell · 2008Article
- Review
- Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrate here that the E2F1 induced by DNA damage can bind to and promote the apoptotic function of p53 via the cyclin A binding site of E2F1. This function of E2F1 does not require its DP-1 binding, DNA binding, or transcriptional activity and is independent of mdm2. All the cyclin A binding E2F family members can interact and cooperate with p53 to induce apoptosis. This suggests a novel role for E2F in regulating apoptosis in response to DNA damage. Cyclin A, but not cyclin E, prevents E2F1 from interacting and cooperating with p53 to induce apoptosis. However, in response to DNA damage, cyclin A levels decrease, with a concomitant increase in E2F1-p53 complex formation. These results suggest that the binding of E2F1 to p53 can specifically stimulate the apoptotic function of p53 in response to DNA damage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.