ArticleMolecular and cellular biology2002
Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Trial
- CaMKIV negatively regulates osteoblast differentiation by modulating c-Fos and NFATc1 signaling: an in vitro and in vivo mechanistic study.BMB reports · 2026Article
- Mining of Targeted Therapeutic Drugs for Hepatocellular Carcinoma based on Programmed Cell Death-related Features and Construction of an Imaging Histology Diagnostic Model.Current topics in medicinal chemistry · 2025Article
- Put in a "CaCells · 2022Review
- Article
- CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.Nature communications · 2019Article
- CREB signals as PBMC-based biomarkers of cognitive dysfunction: A novel perspective of the brain-immune axis.Brain, behavior, and immunity · 2019Review
- The Multi-Functional Calcium/Calmodulin Stimulated Protein Kinase (CaMK) Family: Emerging Targets for Anti-Cancer Therapeutic Intervention.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Calcium/Calmodulin-Dependent Protein Kinase IV (CaMKIV) Mediates Acute Skeletal Muscle Inflammatory Response.Inflammation · 2018Article
- Reduced pCREB in Alzheimer's disease prefrontal cortex is reflected in peripheral blood mononuclear cells.Molecular psychiatry · 2016Article
- Article
- Immunity to viruses: learning from successful human vaccines.Immunological reviews · 2013Review
- Variability in the immune system: of vaccine responses and immune states.Current opinion in immunology · 2013Review
- Systems vaccinology: its promise and challenge for HIV vaccine development.Current opinion in HIV and AIDS · 2012Review
- A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation.Journal of leukocyte biology · 2011Article
- Systems biology of vaccination for seasonal influenza in humans.Nature immunology · 2011Article
- Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification.The Journal of biological chemistry · 2009Article
- Calcium signaling in neurodegeneration.Molecular neurodegeneration · 2009Article
- Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation.Immunological reviews · 2009Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ca(2+)/calmodulin-dependent protein kinase IV-deficient (CaMKIV(-/-)) mice have been used to investigate the role of this enzyme in CD4(+) T cells. We identify a functional defect in a subpopulation of CD4(+) T cells, characterized by a cell surface marker profile usually found on memory phenotype CD4(+) T cells. Upon T-cell receptor engagement, the mutant cells produce diminished levels of interleukin-2 (IL-2), IL-4, and gamma interferon protein and mRNA. The defect is secondary to an inability to phosphorylate CREB and to induce CREB-dependent immediate-early genes, including c-jun, fosB, fra2, and junB, which are required for cytokine gene induction. In contrast, stimulated naive CD4(+) T cells from CaMKIV(-/-) mice show normal CREB phosphorylation, induction of immediate-early genes, and cytokine production. Thus, in addition to defining an important signaling role for CaMKIV in a subpopulation of T cells, we identify differential signaling requirements for cytokine production between naive T cells and T cells that express cell surface markers characteristic of the memory phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.