ArticleJournal of virology2002
Envelope glycoprotein cytoplasmic domains from diverse lentiviruses interact with the prenylated Rab acceptor.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Truncation of the Cytoplasmic Tail of Equine Infectious Anemia Virus Increases Virion Production by Improving Env Cleavage and Plasma Membrane Localization.Journal of virology · 2021Article
- Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein.Nature communications · 2020Article
- The frantic play of the concealed HIV envelope cytoplasmic tail.Retrovirology · 2013Review
- The tale of the long tail: the cytoplasmic domain of HIV-1 gp41.Journal of virology · 2013Review
- A role for prenylated rab acceptor 1 in vertebrate photoreceptor development.BMC neuroscience · 2012Article
- Identification of cellular proteins required for replication of human immunodeficiency virus type 1.AIDS research and human retroviruses · 2012Article
- The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1.Cell host & microbe · 2012Article
- Retroviral env glycoprotein trafficking and incorporation into virions.Molecular biology international · 2012Article
- HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation.Journal of molecular biology · 2011Review
- Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration.Molecular & cellular proteomics : MCP · 2011Article
- Mechanisms for Env glycoprotein acquisition by retroviruses.AIDS research and human retroviruses · 2011Review
- Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein.Journal of virology · 2010Article
- Kinetic studies of HIV-1 and HIV-2 envelope glycoprotein-mediated fusion.Retrovirology · 2006Article
- Virion envelope content, infectivity, and neutralization sensitivity of simian immunodeficiency virus.Journal of virology · 2005Article
- Modulation of Env content in virions of simian immunodeficiency virus: correlation with cell surface expression and virion infectivity.Journal of virology · 2004Article
- Human immunodeficiency virus type 1 envelope glycoproteins that lack cytoplasmic domain cysteines: impact on association with membrane lipid rafts and incorporation onto budding virus particles.Journal of virology · 2004Article
- Targeting of the human immunodeficiency virus type 1 envelope to the trans-Golgi network through binding to TIP47 is required for env incorporation into virions and infectivity.Journal of virology · 2003Article
- Interactions of rotavirus VP4 spike protein with the endosomal protein Rab5 and the prenylated Rab acceptor PRA1.Journal of virology · 2003Article
- Article
- Characterization of a cytolytic strain of equine infectious anemia virus.Journal of virology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Lentivirus envelope glycoproteins have unusually long cytoplasmic domains compared to those of other retroviruses. To identify cellular binding partners of the simian immunodeficiency virus (SIV) envelope transmembrane protein (gp41) cytoplasmic domain (CD), we performed a yeast two-hybrid screen of a phytohemagglutinin-activated human T-cell cDNA library with the SIV gp41 CD. The majority of positive clones (50 of 54) encoded the prenylated Rab acceptor (PRA1). PRA1 is a 21-kDa protein associated with Golgi membranes that binds to prenylated Rab proteins in their GTP-bound state. While the cellular function of PRA1 is presently unknown, this protein appears to participate in intracellular vesicular trafficking, based on its cellular localization and ability to bind multiple members of the Rab protein family. Mammalian two-hybrid assays confirmed the interaction between the SIV gp41 CD and PRA1. Furthermore, gp41 sequences important for PRA1 binding were mapped to a central leucine-rich, amphipathic alpha-helix in the SIV gp41 cytoplasmic tail. Although the human immunodeficiency virus (HIV-1) gp41 CD failed to interact with PRA1 in the yeast two-hybrid system, its interaction with PRA1 was significantly better than that of the SIV gp41 CD in mammalian two-hybrid assays. Interestingly, PRA1 also interacted with the Env CDs of HIV-2, bovine immunodeficiency virus, equine infectious anemia virus, and feline immunodeficiency virus. Thus, PRA1 associates with envelope glycoproteins from widely divergent lentiviruses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.