ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
The permissive cue laminin is essential for growth cone turning in vivo.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
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- Characterization of Regenerative Phenotype of Unrestricted Somatic Stem Cells (USSC) from Human Umbilical Cord Blood (hUCB) by Functional Secretome Analysis.Molecular & cellular proteomics : MCP · 2015Article
- Neural cell alignment by patterning gradients of the extracellular matrix protein laminin.Interface focus · 2014Article
- Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.Developmental neurobiology · 2011Review
- In vivo imaging of cell behaviors and F-actin reveals LIM-HD transcription factor regulation of peripheral versus central sensory axon development.Neural development · 2011Article
- Cortical deficiency of laminin gamma1 impairs the AKT/GSK-3beta signaling pathway and leads to defects in neurite outgrowth and neuronal migration.Developmental biology · 2009Article
- Transient axonal glycoprotein-1 (TAG-1) and laminin-alpha1 regulate dynamic growth cone behaviors and initial axon direction in vivo.Neural development · 2008Article
- Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps.Biomaterials · 2008Article
- Genome-wide analyses of human perisylvian cerebral cortical patterning.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Rac1 and RhoA promote neurite outgrowth through formation and stabilization of growth cone point contacts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Gradient steepness influences the pathfinding decisions of neuronal growth cones in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- The critical role of basement membrane-independent laminin gamma 1 chain during axon regeneration in the CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proper guidance of migrating growth cones relies on the balance of multiple guidance cues in the embryonic environment. In addition to guidance cues, growth cones are in contact with other substrates that may contribute to the pathfinding of neurons. For example, in the developing insect peripheral nervous system, pioneer neurons migrate on and between layers of the basal lamina. Previous studies have demonstrated that one basal lamina molecule, laminin, promotes outgrowth of many classes of neurons in vitro. In this study, the simple grasshopper nervous system was used to investigate the role of laminin in neuronal pathfinding. Laminin expression precedes axonogenesis of the Tibial (Ti1) pioneer neurons in the developing limb bud, and expression continues during outgrowth and guidance of the pioneer neurons. The role of a nidogen-binding motif on laminin was investigated using subunit-specific antibodies and peptides as blocking reagents in vivo. Antibodies and peptides that block the nidogen-binding site on laminin resulted in stalled Ti1 axon migration, predominantly at the precise location where they normally turn ventrally. After prolonged culturing, Ti1 axons remained stalled at the same location. Therefore, although Ti1 axons were capable of outgrowth in the presence of blocking reagents, they were not able to navigate an essential turn. This study indicates that the interaction of the Ti1 growth cone with the nidogen-binding site on laminin is vital for neuronal pathfinding in vivo and suggests that permissive cues may be essential for growth cone steering.
Indexed as
Identifiers
11739586PMC6763034W2141471265What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.