ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Roles for mitochondrial and reverse mode Na+/Ca2+ exchange and the plasmalemma Ca2+ ATPase in post-tetanic potentiation at crayfish neuromuscular junctions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 85 citations in OpenAlex.
- Mitochondrial Mutations Can Alter Neuromuscular Transmission in Congenital Myasthenic Syndrome and Mitochondrial Disease.International journal of molecular sciences · 2023Review
- Mitochondrial calcium cycling in neuronal function and neurodegeneration.Frontiers in cell and developmental biology · 2023Review
- Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation.Communications biology · 2021Article
- Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Organelle-Specific Sensors for Monitoring CaFrontiers in synaptic neuroscience · 2016Review
- Article
- Mechanisms underlying presynaptic Ca2+ transient and vesicular glutamate release at a CNS nerve terminal during in vitro ischaemia.The Journal of physiology · 2015Article
- Presynaptic control of glycine transporter 2 (GlyT2) by physical and functional association with plasma membrane Ca2+-ATPase (PMCA) and Na+-Ca2+ exchanger (NCX).The Journal of biological chemistry · 2014Article
- Slack, Slick and Sodium-Activated Potassium Channels.ISRN neuroscience · 2013Article
- Functional contributions of the plasma membrane calcium ATPase and the sodium-calcium exchanger at mouse parallel fibre to Purkinje neuron synapses.Pflugers Archiv : European journal of physiology · 2013Article
- Short-term presynaptic plasticity.Cold Spring Harbor perspectives in biology · 2012Review
- Plasmalemmal Na+/Ca2+ exchanger modulates Ca2+-dependent exocytotic release of glutamate from rat cortical astrocytes.ASN neuro · 2012Article
- Immunophilin deficiency augments Ca2+-dependent glutamate release from mouse cortical astrocytes.Cell calcium · 2011Article
- Sympathetic nerves and the endothelium influence the vasoconstrictor effect of low concentrations of ouabain in pressurized small arteries.American journal of physiology. Heart and circulatory physiology · 2010Article
- Mitochondria modulate Ca2+-dependent glutamate release from rat cortical astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Short-term potentiation of mEPSCs requires N-, P/Q- and L-type Ca2+ channels and mitochondria in the supraoptic nucleus.The Journal of physiology · 2008Article
- Mechanisms of prolonged presynaptic Ca2+ signaling and glutamate release induced by TRPV1 activation in rat sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Facilitating exchange: activity-dependent regulation of presynaptic Na+/Ca2+ exchange.The Journal of physiology · 2008Review
- Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Increased Ca2+ influx through Na+/Ca2+ exchanger during long-term facilitation at crayfish neuromuscular junctions.The Journal of physiology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have explored the processes regulating presynaptic calcium concentration ([Ca(2+)](i)) in the generation of post-tetanic potentiation (PTP) at crayfish neuromuscular junctions, using spectrophotometric dyes to measure changes in [Ca(2+)](i) and [Na(+)](i) and effects of inhibitors of Ca(2+)-transport processes. The mitochondrial Na(+)/Ca(2+) exchange inhibitor CGP 37157 was without effect, whereas the reverse mode plasmalemmal Na(+)/Ca(2+) exchange inhibitor KB R7943 reduced PTP and Ca(2+) accumulation caused by increased [Na(+)](i). Exchange inhibitory peptide and C28R2 had opposite effects, consistent with their block of the plasma membrane Ca(2+) ATPase. All drugs except CGP 37157 reduced Ca(2+) accumulation caused by Na(+) accumulation, which occurred on block of the Na(+)/K(+) pump, acting in proportion to their effects on plasmalemmal Na(+)/Ca(2+) exchange. We find no role for mitochondrial Na(+)/Ca(2+) exchange in presynaptic Ca(2+) regulation. The plasma membrane Na(+)/Ca(2+) exchanger acts in reverse mode to admit Ca(2+) into nerve terminals during and for some minutes after tetanic stimulation, while at the same time the plasma membrane Ca(2+) ATPase operates as an important Ca(2+) removal process. The interplay of these two Ca(2+) transport processes with Na(+)-independent mitochondrial Ca(2+) fluxes and the plasmalemma Na(+)/K(+) pump determines the magnitude of tetanic [Ca(2+)](i) accumulation and potentiation of excitatory transmission, and the post-tetanic time courses of decay of elevated [Ca(2+)](i) and PTP.
Indexed as
Identifiers
11739570PMC6763056W2166321238What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.