ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Rapid redistribution of the postsynaptic density protein PSD-Zip45 (Homer 1c) and its differential regulation by NMDA receptors and calcium channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- TMEM132A promotes cervical cancer progression via HOMER3-mediated activation of FAK/PI3K/AKT signaling pathway.Scientific reports · 2026Article
- Increased Homer Activity and NMJ Localization in the Vestibular LesionInternational journal of molecular sciences · 2024Article
- Article
- Spine dynamics in the brain, mental disorders and artificial neural networks.Nature reviews. Neuroscience · 2021Review
- Regional Brain Recovery from Acute Synaptic Injury in Simian Immunodeficiency Virus-Infected Rhesus Macaques Associates with Heme Oxygenase Isoform Expression.Journal of virology · 2020Article
- CD40L Reverse Signaling Influences Dendrite Spine Morphology and Expression of PSD-95 and Rho Small GTPases.Frontiers in cell and developmental biology · 2020Article
- Activity-Dependent Remodeling of Synaptic Protein Organization Revealed by High Throughput Analysis of STED Nanoscopy Images.Frontiers in neural circuits · 2020Article
- Mapping molecular assemblies with fluorescence microscopy and object-based spatial statistics.Nature communications · 2018Article
- Self-crowding of AMPA receptors in the excitatory postsynaptic density can effectuate anomalous receptor sub-diffusion.PLoS computational biology · 2018Article
- Spatial distribution and molecular dynamics of dystrophin glycoprotein components at the neuromuscular junctionJournal of cell science · 2017Article
- Fluorescence imaging of synapse dynamics in normal circuit maturation and in developmental disorders.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Review
- Relative Contributions of Specific Activity Histories and Spontaneous Processes to Size Remodeling of Glutamatergic Synapses.PLoS biology · 2016Article
- Tuning the Binding Affinities and Reversion Kinetics of a Light Inducible Dimer Allows Control of Transmembrane Protein Localization.Biochemistry · 2016Article
- Neuronal activity controls transsynaptic geometry.Scientific reports · 2016Article
- Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity.Nature communications · 2016Article
- Article
- Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model.Cell reports · 2015Article
- Fluorescent ratiometric pH indicator SypHer2: Applications in neuroscience and regenerative biology.Biochimica et biophysica acta · 2015Article
- Live imaging of endogenous PSD-95 using ENABLED: a conditional strategy to fluorescently label endogenous proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.Neuroscience · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PSD-Zip45 (Homer 1c) and PSD-95 are postsynaptic density (PSD) proteins containing distinct protein-interacting motifs. Green fluorescent protein (GFP)-tagged PSD-Zip45 and PSD-95 molecules were targeted to the PSD in hippocampal neurons. We analyzed dynamic behavior of these GFP-tagged PSD proteins by using time-lapse confocal microscopy. In contrast to the less dynamic properties of PSD-95, PSD-Zip45 showed rapid redistribution and a higher steady-state turnover rate. Differential stimulation protocols were found to alter the direction of PSD-Zip45 assembly-disassembly. Transient increases in intracellular Ca(2+) by voltage-dependent Ca(2+) channel activation induced PSD-Zip45 clustering. In contrast, NMDA receptor-dependent Ca(2+) influx resulted in the disassembly of PSD-Zip45 clusters. Thus, neuronal activity differentially redistributes a specific subset of PSD proteins, which are important for localization of both surface receptors and intracellular signaling complexes.
Indexed as
Identifiers
11739567PMC6763022What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.