ArticleThe Journal of cell biology2001
Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 123 citations in OpenAlex.
- Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance).Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Trial
- Axin Family of Scaffolding Proteins in Development: Lessons fromJournal of developmental biology · 2019Review
- Co‑expression of Axin and APC gene fragments inhibits colorectal cancer cell growth via regulation of the Wnt signaling pathway.Molecular medicine reports · 2017Article
- Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions.EMBO molecular medicine · 2017Article
- Endothelial Wnt/β-catenin signaling reduces immune cell infiltration in multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mammary gland stem cells and their application in breast cancer.Oncotarget · 2017Review
- The crossroads of breast cancer progression: insights into the modulation of major signaling pathways.OncoTargets and therapy · 2017Review
- Deregulation of the Hippo pathway in mouse mammary stem cells promotes mammary tumorigenesis.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Identification of p53-target genes in Danio rerio.Scientific reports · 2016Article
- Article
- Wnt/catenin signaling in adult stem cell physiology and disease.Stem cell reviews and reports · 2014Review
- GSK-3 as potential target for therapeutic intervention in cancer.Oncotarget · 2014Review
- Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification.Biochemical and biophysical research communications · 2013Article
- A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.Bone research · 2013Review
- Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis.PloS one · 2013Article
- Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling.Cold Spring Harbor perspectives in biology · 2012Review
- Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Axin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cells.PloS one · 2012Article
- Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.PloS one · 2010Article
- Wnt and mammary stem cells: hormones cannot fly wingless.Current opinion in pharmacology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axin is a component of the canonical Wnt pathway that negatively regulates signal transduction by promoting degradation of beta-catenin. To study the role of Axin in development, we developed strains of transgenic mice in which its expression can be manipulated by the administration of doxycycline (Dox). Animals carrying both mouse mammary tumor virus (MMTV)-reverse tetracycline transactivator and tetracycline response element (TRE)2-Axin-green fluorescent protein (GFP) transgenes exhibited Dox-dependent Axin expression and, when induced from birth, displayed abnormalities in the development of mammary glands and lymphoid tissues, both sites in which the MMTV promoter is active. The transgenic mammary glands underwent normal ductal elongation and side branching during sexual maturation and early pregnancy, but failed to develop lobulo-alveoli, resulting in a defect in lactation. Axin attenuated the expression of cyclin D1, a Wnt target that promotes the growth and differentiation of mammary lobulo-alveoli. Increased apoptosis occurred in the mammary epithelia, consistent with the inhibition of a Wnt/cyclin D1 survival signal by Axin. High levels of programmed cell death also occurred in the thymus and spleen. Immature thymocytes underwent massive apoptosis, indicating that the overexpression of Axin blocks the normal development of T lymphocytes. Our data imply that the Axin tumor suppressor controls cell survival, growth, and differentiation through the regulation of an apoptotic signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.