ArticleThe Journal of cell biology2001
A t-SNARE of the endocytic pathway must be activated for fusion.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 66 citations in OpenAlex.
- The SNARE-associated protein Sft2 functions in Imh1-mediated SNARE recycling transport upon ER stress.Molecular biology of the cell · 2023Article
- The yeast endocytic early/sorting compartment exists as an independent sub-compartment within theeLife · 2023Article
- Retrograde trafficking and quality control of yeast synaptobrevin, Snc1, are conferred by its transmembrane domain.Molecular biology of the cell · 2019Article
- SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Multiple and distinct strategies of yeast SNAREs to confer the specificity of membrane fusion.Scientific reports · 2014Article
- Tracing putative trafficking of the glycolytic enzyme enolase via SNARE-driven unconventional secretion.Eukaryotic cell · 2012Article
- A novel function for SNAP29 (synaptosomal-associated protein of 29 kDa) in mast cell phagocytosis.PloS one · 2012Article
- Organization of SNAREs within the Golgi stack.Cold Spring Harbor perspectives in biology · 2011Review
- The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport.The Journal of cell biology · 2011Article
- Article
- Protein determinants of SNARE-mediated lipid mixing.Biophysical journal · 2010Article
- Article
- Binding interactions control SNARE specificity in vivo.The Journal of cell biology · 2008Article
- Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies.The EMBO journal · 2007Article
- SNAREs can promote complete fusion and hemifusion as alternative outcomes.The Journal of cell biology · 2005Article
- Control of Ste6 recycling by ubiquitination in the early endocytic pathway in yeast.Molecular biology of the cell · 2005Article
- Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Sec1p directly stimulates SNARE-mediated membrane fusion in vitro.The Journal of cell biology · 2004Article
- Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack.Molecular biology of the cell · 2004Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The t-SNARE in a late Golgi compartment (Tlg2p) syntaxin is required for endocytosis and localization of cycling proteins to the late Golgi compartment in yeast. We show here that Tlg2p assembles with two light chains, Tlg1p and Vti1p, to form a functional t-SNARE that mediates fusion, specifically with the v-SNAREs Snc1p and Snc2p. In vitro, this t-SNARE is inert, locked in a nonfunctional state, unless it is activated for fusion. Activation can be mediated by a peptide derived from the v-SNARE, which likely bypasses additional regulatory proteins in the cell. Locking t-SNAREs creates the potential for spatial and temporal regulation of fusion by signaling processes that unleash their fusion capacity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.