ReviewRespiratory research2001
The role of collagenase in emphysema.
Review in Respiratory research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Airway cell-cell communication in smoking through integration of spatial and single-cell transcriptomics.Respiratory research · 2026Article
- Airway Spatial Transcriptomics in Smoking.medRxiv : the preprint server for health sciences · 2025Article
- Lung function in adult patients with osteogenesis imperfecta: a cohort study.Orphanet journal of rare diseases · 2024Article
- MAP2K1 dampens cigarette smoke-induced inflammation via suppression of type I interferon pathway activation.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- The Role of the Extracellular Matrix in the Pathogenesis and Treatment of Pulmonary Emphysema.International journal of molecular sciences · 2024Review
- Collagen deposition in lung parenchyma driven by depletion of interstitial Lyve-1Frontiers in immunology · 2024Article
- Bulb ofJournal of microbiology and biotechnology · 2023Article
- Extracellular matrix in lung development, homeostasis and disease.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Matrix Metalloproteinase-28 Is a Key Contributor to Emphysema Pathogenesis.The American journal of pathology · 2017Article
- Theoretical diagnosis of emphysema by aerosol bolus inhalation.Annals of translational medicine · 2017Article
- A flavanone from Baccharis retusa (Asteraceae) prevents elastase-induced emphysema in mice by regulating NF-κB, oxidative stress and metalloproteinases.Respiratory research · 2015Article
- Amplified and selective assay of collagens by enzymatic and fluorescent reactions.Scientific reports · 2014Article
- Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation.PloS one · 2013Article
- STAT3 modulates cigarette smoke-induced inflammation and protease expression.Frontiers in physiology · 2013Article
- TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease.The Journal of biological chemistry · 2011Article
- Human T cells stimulate fibroblast-mediated degradation of extracellular matrix in vitro.Clinical and experimental immunology · 2008Article
- Mechanical ventilation and lung infection in the genesis of air-space enlargement.Critical care (London, England) · 2007Article
- The genetics of chronic obstructive pulmonary disease.Respiratory research · 2006Review
- Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues.The American journal of pathology · 2005Article
- Chronic obstructive pulmonary disease - part 2: pathology and biochemistry of emphysema.Thorax · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The extracellular matrix is essential for the integrity of the lung and when disrupted can lead to the architectural changes seen in emphysema. The etiology of emphysema is believed to be due to an imbalance in the proteases and antiproteases within the lung. Studies have focused on elastolytic enzymes as the primary agents in disease pathogenesis, however, recent data suggest that collagenases may also be involved in the destruction of lung tissue in emphysema. It is hoped that this expanded understanding of the pathophysiology of emphysema will lead to improved therapy in the treatment of the disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.