Trial reportCritical care (London, England)2001
Red blood cell transfusion does not increase oxygen consumption in critically ill septic patients.
Trial report in Critical care (London, England), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 6 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- Effects of rapid fluid infusion on hemoglobin concentration: a systematic review and meta-analysis.Critical care (London, England) · 2022Pooled it
- Methodological Aspects of Indirect Calorimetry in Patients with Sepsis-Possibilities and Limitations.Nutrients · 2022Pooled it
- Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review.Critical care (London, England) · 2013Pooled it
- A new perspective on best transfusion practices.Blood transfusion = Trasfusione del sangue · 2013Guideline
- Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.Intensive care medicine · 2013Guideline
- Impact of red blood cell transfusion on oxygen transport and metabolism in patients with sepsis and septic shock: a systematic review and meta-analysis.Revista Brasileira de terapia intensivaPooled it
- Red blood cell transfusion and outcomes in patients with acute lung injury, sepsis and shock.Critical care (London, England) · 2011Trial
- Blood transfusions in septic shock: is 7.0 g/dL really the appropriate threshold?Revista Brasileira de terapia intensivaTrial
- Crossing the line: blood transfusion thresholds in ECMO.Critical care (London, England) · 2025Article
- Investigating the feasibility of machine learning to guide personalized red blood cell (RBC) transfusion: analyzing the heterogeneity of RBC transfusion in septic patients with hemoglobin levels of 7-9 g/dL based on the causal forest model.Frontiers in pharmacology · 2025Article
- Dielectrophoretic profiling of erythrocytes to study the impacts of metabolic stress, temperature, and storage duration utilizing a point-and-planar microdevice.Scientific reports · 2023Article
- Short-term effects of stored homologous red blood cell transfusion on cardiorespiratory function and inflammation: an experimental study in a hypovolemia model.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Transfusion of fresh vs. older red blood cells in the context of infection.ISBT science series · 2015Article
- Indications for blood and blood product transfusion.Indian journal of anaesthesia · 2014Review
- Factors Affecting Tissue Oxygenation in Erythrocyte Transfusions.Turkish journal of anaesthesiology and reanimation · 2014Review
- Does prolonged storage of red blood cells cause harm?British journal of haematology · 2014Review
- Anaemia secondary to critical illness: an unexplained phenomenon.Extreme physiology & medicine · 2014Article
- How cell number and cellular properties of blood-banked red blood cells of different cell ages decline during storage.PloS one · 2014Article
- Effects of different types of hydroxyethyl starch (HES) on microcirculation perfusion and tissue oxygenation in patients undergoing liver surgery.International journal of clinical and experimental medicine · 2014Article
- Anemia and transfusion of red blood cells.Colombia medica (Cali, Colombia) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRed blood cell (RBC) transfusion is commonly used to increase oxygen transport in patients with sepsis. However it does not consistently increase oxygen uptake at either the whole-body level, as calculated by the Fick method, or within individual organs, as assessed by gastric intra-mucosal pH.
aimThis study evaluates the hemodynamic and oxygen utilization effects of hemoglobin infusion on critically ill septic patients.
methodsFifteen septic patients undergoing mechanical ventilation whose hemoglobin was <10 g% were eligible. Ten patients (APACHE II: 25.5 +/- 7.6) received an infusion of 1 unit of packed RBC over 1 h while sedated and paralyzed. The remaining five control patients (APACHE II: 24.3 +/- 6.0) received a 5% albumin solution (500 ml) over 1 h. Hemodynamic data, gastric tonometry and calorimetry were obtained prior to and immediately after RBC transfusion or 5% albumin infusion.
resultsTransfusion of RBC was associated with an improvement in left ventricular systolic work index (38.6 +/- 12.6 to 41.1 +/- 13.0 g/min/m2; P = 0.04). In the control group there was no significant change in the left ventricular systolic work index (37.2 +/- 14.3 to 42.2 +/- 18.9 g/min/m2). An increase in pulmonary vascular resistance index (203 +/- 58 to 238 +/- 49 dyne/cm5/m2; P = 0.04) was also observed, while no change was produced by colloid infusion (237 +/- 87.8 to 226.4 +/- 57.8 dyne/cm5/m2). Oxygen utilization did not increase either by Fick equation or by indirect calorimetry in either group. Gastric intramucosal pH increased only in the control group but did not reach statistical significance.
conclusionHemoglobin increase does not improve either global or regional oxygen utilization in anemic septic patients. Furthermore, RBC transfusion may hamper right ventricular ejection by increasing the pulmonary vascular resistance index.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.