ArticleClinical and experimental immunology2001
Cytokine receptor signalling in neonatal macrophages: defective STAT-1 phosphorylation in response to stimulation with IFN-gamma.
Article in Clinical and experimental immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 79 citations in OpenAlex.
- Neonatal Immune Responses to Respiratory Viruses.Frontiers in immunology · 2022Review
- Prenatal Immunity and Influences on Necrotizing Enterocolitis and Associated Neonatal Disorders.Frontiers in immunology · 2021Review
- Dysregulated Mucosal Immunity and Associated Pathogeneses in Preterm Neonates.Frontiers in immunology · 2020Review
- Maternal-Fetal Interplay in Zika Virus Infection and Adverse Perinatal Outcomes.Frontiers in immunology · 2020Review
- Dissecting the defects in the neonatal CD8Journal of leukocyte biology · 2019Review
- Why are preterm newborns at increased risk of infection?Archives of disease in childhood. Fetal and neonatal edition · 2018Review
- IRF5 Is a Key Regulator of Macrophage Response to Lipopolysaccharide in Newborns.Frontiers in immunology · 2018Article
- Neonatal Immunity, Respiratory Virus Infections, and the Development of Asthma.Frontiers in immunology · 2018Review
- IFN-γ Blocks Development of an Asthma Phenotype in Rhinovirus-Infected Baby Mice by Inhibiting Type 2 Innate Lymphoid Cells.American journal of respiratory cell and molecular biology · 2017Article
- Neonatal Group B Streptococcal Disease in Otherwise Healthy Infants: Failure of Specific Neonatal Immune Responses.Frontiers in immunology · 2017Article
- Cystatin B and HIV regulate the STAT-1 signaling circuit in HIV-infected and INF-β-treated human macrophages.Journal of neurovirology · 2016Article
- Elevated interleukin-27 levels in human neonatal macrophages regulate indoleamine dioxygenase in a STAT-1 and STAT-3-dependent manner.Immunology · 2016Article
- A novel flow cytometric-based method to measure kinase inhibition in sputum from COPD subjects.BMJ open respiratory research · 2016Article
- Ontogeny of myeloid cells.Frontiers in immunology · 2014Review
- Species-dependent differences of embryonic stem cell-derived neural stem cells after Interferon gamma treatment.Frontiers in cellular neuroscience · 2012Article
- ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation.PLoS pathogens · 2011Article
- The interaction between PRRSV and the late gestation pig fetus.Virus research · 2010Review
- Neonatal sepsis and neutrophil insufficiencies.International reviews of immunology · 2010Article
- Development and application of 'phosphoflow' as a tool for immunomonitoring.Expert review of vaccines · 2010Review
- Defective antigen-presenting cell function in human neonates.Clinical immunology (Orlando, Fla.) · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reported earlier that neonatal monocyte-derived macrophages (MDM) could not be fully activated with IFN-gamma, a finding that could not be attributed to lower expression of IFN-gamma receptors on the neonatal cells. In this study we explored elements of IFN-gamma R-mediated signalling in cord monocytes and MDM. Intracellular expression of STAT-1 was analysed by flow cytometry. We have assessed phosphorylation of STAT-1 by using MoAbs that distinguish native and phosphorylated forms of STAT-1 on a discrete cell basis. Using MoAbs against the native form of STAT-1 revealed comparable expression of this protein in cord and adult cells (both monocytes and MDM). However, STAT-1 phosphorylation in response to IFN-gamma was significantly decreased in neonatal monocytes (P < 0.05) and MDM (P < 0.01) compared to adult cells (n > 5 for each). These data suggest deficient cytokine-receptor signalling in neonatal mononuclear phagocytes exposed to IFN-gamma. We propose that decreased STAT-1 phosphorylation and activation may represent developmental immaturity and may contribute to the unique susceptibility of neonates to infections by intracellular pathogens.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.