ArticleClinical and experimental immunology2001
MHC class I chain-like gene A (MICA) and its associations with inflammatory bowel disease and peripheral arthropathy.
Article in Clinical and experimental immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 73 citations in OpenAlex.
- A Multitrait Analysis of Genome-Wide Association Study Reveals the Shared Genetic Architecture Between Inflammatory Bowel Disease and Ankylosing Spondylitis.Mediators of inflammation · 2025Article
- Impact of MICA 3'UTR allelic variability on miRNA binding prediction, a bioinformatic approach.Frontiers in genetics · 2023Article
- Integration of Transcriptome and Exome Genotyping Identifies Significant Variants with Autism Spectrum Disorder.Pharmaceuticals (Basel, Switzerland) · 2022Article
- MICA and NKG2D variants as risk factors in spondyloarthritis: a case-control study.Genes and immunity · 2019Article
- Anti-NKG2D mAb: A New Treatment for Crohn's Disease?International journal of molecular sciences · 2017Review
- NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8Experimental and molecular pathology · 2017Article
- How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation.Frontiers in immunology · 2017Review
- MICA*A4 protects against ulcerative colitis, whereas MICA*A5.1 is associated with abscess formation and age of onset.Clinical and experimental immunology · 2016Article
- Allele Specific Expression of MICA Variants in Human Fibroblasts Suggests a Pathogenic Mechanism.The open rheumatology journal · 2015Article
- Associations of MICA Polymorphisms with Inflammatory Rheumatic Diseases.The open rheumatology journal · 2015Article
- Immunogenetic biomarkers in inflammatory bowel diseases: role of the IBD3 region.World journal of gastroenterology · 2014Review
- MICA, a gene contributing strong susceptibility to ankylosing spondylitis.Annals of the rheumatic diseases · 2014Article
- Immunomodulation at epithelial sites by obesity and metabolic disease.Immunologic research · 2012Review
- Enteropathic spondyloarthropathy: a common genetic background with inflammatory bowel disease?World journal of gastroenterology · 2009Review
- Defining the role of the MHC in autoimmunity: a review and pooled analysis.PLoS genetics · 2008Review
- In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer.PloS one · 2007Article
- Extraintestinal manifestations and complications in inflammatory bowel diseases.World journal of gastroenterology · 2006Review
- NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?Genes and immunity · 2004Article
- Choosing Therapy on the Basis of Disease Classifications in Inflammatory Bowel Disease.Current treatment options in gastroenterology · 2004Article
- MICA, HLA-B haplotypic variation in five population groups of sub-Saharan African ancestry.Genes and immunity · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MHC class I chain gene A (MICA) is a non-classical Class I gene which is expressed on the surface of epithelia without beta 2-microglobulin. The gene is found in the major histocompatibility complex (MHC) in tight linkage disequilibrium with human leucocyte antigen-B (HLA-B). Its precise function is unknown, but it interacts with gamma delta T cells of the intestinal immune system. This region of the MHC has been implicated in inflammatory bowel disease (IBD) pathogenesis by recent association mapping studies and this study was performed to examine the prevalence of MICA gene polymorphisms in IBD, in particular in type 2 peripheral arthropathy (PeA), which also has a strong HLA-B association. An assessment of the prevalence of MICA polymorphisms in IBD was made. Blood from 50 ulcerative colitis (UC) and 50 Crohn's disease controls was taken and MICA status determined using allele-specific PCR for 16 known alleles of MICA. A further 91 UC patients were recruited to confirm the results of this stage, and then the polymorphisms were studied in 52 type 1 and 45 type 2 PeA patients. The MICA status of these groups was compared with 118 blood and organ donor controls with appropriate correction for multiple comparisons. UC overall was associated with possession of MICA*007 in 32% compared to 11% of controls (P(c) = 0.017). This association was confirmed in a second cohort of 91 patients (23% versus 11%, P = 0.02). These were independent of HLA class I status. Type 2 IBD PeA was associated with MICA*008 in 98% compared to 73% of controls (P = 0.0001). MICA*007 is associated with susceptibility to UC in our population and MICA*008 with type 2 IBD PeA. Further work is now required to assess the distribution and expression of MICA throughout the gut in health and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.