ReviewDrug safety2001
Treating epilepsy in the elderly: safety considerations.
Review in Drug safety, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 47 citations in OpenAlex.
- Status epilepticus in older adults: A critical review.Epilepsia · 2025Review
- Primary treatment gap among adults with epilepsy: A cross-sectional analysis.Epileptic disorders : international epilepsy journal with videotape · 2024Article
- Traditional and Novel Migraine Therapy in the Aging Population.Current pain and headache reports · 2019Review
- Seizure in Alzheimer's Disease: An Underestimated Phenomenon.American journal of Alzheimer's disease and other dementias · 2019Review
- Selection of antiepileptic drugs in older people.Current treatment options in neurology · 2014Article
- Pathophysiological considerations of seizures, epilepsy, and status epilepticus in the elderly.Aging and disease · 2011Article
- Review of topiramate for the treatment of epilepsy in elderly patients.Clinical interventions in aging · 2010Review
- [Seizures and epilepsies after stroke].Der Nervenarzt · 2009Review
- Epilepsy in elderly people.BMJ (Clinical research ed.) · 2005Review
- Review
- Seizures in elderly patients with dementia: epidemiology and management.Drugs & aging · 2003Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of epilepsy increases with advancing age. Epilepsy in the elderly has different aetiologies from that in younger populations, cerebrovascular disease being the most common condition associated with seizures. Partial seizures are the predominant seizure type in older patients. A diagnosis of epilepsy in the elderly is based mainly on the history and is frequently delayed. In addition, seizure imitators are especially frequent. In many cases ancillary tests for diagnosis may show normal age-related variants, sometimes making results difficult to interpret. Treating epilepsy in the elderly is problematic due to a number of issues that relate to age and comorbidity. The physical changes associated with increasing age frequently lead to changes in the pharmacokinetics of many anticonvulsants. The treatment of epilepsy in the elderly is also complicated by the existence of other diseases that might affect the metabolism or excretion of anticonvulsants and the presence of concomitant medications that might interact with them. Moreover, specific trials of anticonvulsants in the aged population are scarce. General guidelines for treatment include starting at lower doses, slowing the titration schedule, individualising the choice of anticonvulsant to the characteristics of the patient, avoiding anticonvulsants with important cognitive or sedative adverse effects, and where possible, treating with monotherapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.