ReviewCNS drugs2001
Magnesium for neuroprotection in ischaemic stroke: rationale for use and evidence of effectiveness.
Review in CNS drugs, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06956521 (Intra-Arterial Magnesium Therapy After Mechanical Thrombectomy in Acute Ischemic Stroke), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intra-Arterial Magnesium Therapy After Mechanical Thrombectomy in Acute Ischemic Stroke
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Magnesium in stroke treatment.Postgraduate medical journal · 2002Pooled it
- Prehospital neuroprotectant in combination with post-arrival thrombolytic therapy for acute ischemic stroke. Secondary analysis of the FAST-MAG prehospital trial.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026Trial
- Effect of Magnesium on Deterioration and Symptomatic Hemorrhagic Transformation in Cerebral Ischemia: An Ancillary Analysis of the FAST-MAG Trial.Cerebrovascular diseases (Basel, Switzerland) · 2023Trial
- Prehospital use of magnesium sulfate as neuroprotection in acute stroke.The New England journal of medicine · 2015Trial
- Methodology of the Field Administration of Stroke Therapy - Magnesium (FAST-MAG) phase 3 trial: Part 1 - rationale and general methods.International journal of stroke : official journal of the International Stroke Society · 2014Trial
- How to Pick a Neuroprotective Drug in Stroke Without Losing Your Mind?Life (Basel, Switzerland) · 2025Review
- Magnesium intake and all-cause mortality after stroke: a cohort study.Nutrition journal · 2023Article
- Does the association of therapeutic exercise and supplementation with sucrosomial magnesium improve posture and balance and prevent the risk of new falls?Aging clinical and experimental research · 2022Article
- Rapid Treatment with Intramuscular Magnesium Sulfate During Cardiopulmonary Resuscitation Does Not Provide Neuroprotection Following Cardiac Arrest.Molecular neurobiology · 2022Article
- Intra-arterial neuroprotective therapy as an adjunct to endovascular intervention in acute ischemic stroke: A review of the literature and future directions.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2020Review
- Magnesium and Hemorrhage Volume in Patients With Aneurysmal Subarachnoid Hemorrhage.Critical care medicine · 2020Observational
- Magnesium sulfate ameliorates carbon monoxide‑induced cerebral injury in male rats.Molecular medicine reports · 2019Article
- Self-powered therapeutic release from conducting polymer/graphene oxide films on magnesium.Nanomedicine : nanotechnology, biology, and medicine · 2018Article
- Hypomagnesemia in critically ill patients.Journal of intensive care · 2018Review
- Observational
- Poly (3,4-ethylenedioxythiophene) graphene oxide composite coatings for controlling magnesium implant corrosion.Acta biomaterialia · 2017Article
- Neuroprotection after major cardiovascular surgery.Current treatment options in neurology · 2015Article
- Imaging of prehospital stroke therapeutics.Expert review of cardiovascular therapy · 2015Review
- Intra-carotid cold magnesium sulfate infusion induces selective cerebral hypothermia and neuroprotection in rats with transient middle cerebral artery occlusion.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- The role of magnesium in the management of cerebral vasospasm.Neurology research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnesium exhibits a range of neuronal and vascular actions that may ameliorate ischaemic CNS insults, including stroke. Significant neuroprotection with magnesium has been observed in different models of focal cerebral ischaemia in many laboratories, with infarct volume reductions between 25 and 61%. Maximal neuroprotection is evident at readily attainable serum concentrations, and neuroprotection is still seen when administration is delayed up to 6 hours after onset of ischaemia. Clinical use of magnesium in pre-eclampsia and acute myocardial infarction confirms its safety and tolerability. Five small trials in acute stroke have reported reduced odds of death or dependence with administration of magnesium, but confidence intervals are wide, and definitive data from ongoing large trials are awaited.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.