ArticleProceedings of the National Academy of Sciences of the United States of America2001
A tumor host range selection procedure identifies p150(sal2) as a target of polyoma virus large T antigen.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer cells.Cell death & disease · 2024Article
- SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes.Molecular oncology · 2018Article
- SALL1 functions as a tumor suppressor in breast cancer by regulating cancer cell senescence and metastasis through the NuRD complex.Molecular cancer · 2018Article
- Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin.Cell death & disease · 2015Article
- The tumor suppressor protein p150(Sal2) in carcinogenesis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- A mouse polyomavirus-encoded microRNA targets the cellular apoptosis pathway through Smad2 inhibition.Virology · 2014Article
- Promoter methylation of the SALL2 tumor suppressor gene in ovarian cancers.Molecular oncology · 2013Article
- Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress.PloS one · 2013Article
- Sall1 regulates cortical neurogenesis and laminar fate specification in mice: implications for neural abnormalities in Townes-Brocks syndrome.Disease models & mechanisms · 2012Article
- The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC.PloS one · 2012Article
- The role of HSAL (SALL) genes in proliferation and differentiation in normal hematopoiesis and leukemogenesis.Transfusion · 2011Article
- Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2).FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- The role of stem cell factor SALL4 in leukemogenesis.Critical reviews in oncogenesis · 2011Review
- Sall1, sall2, and sall4 are required for neural tube closure in mice.The American journal of pathology · 2008Article
- A transcriptional program mediating entry into cellular quiescence.PLoS genetics · 2007Article
- Independent contributions of polyomavirus middle T and small T to the regulation of early and late gene expression and DNA replication.Journal of virology · 2006Article
- Identification of TAZ as a binding partner of the polyomavirus T antigens.Journal of virology · 2004Article
- p150(Sal2) is a p53-independent regulator of p21(WAF1/CIP).Molecular and cellular biology · 2004Article
- Pathogen-host standoff: immunity to polyomavirus infection and neoplasia.Immunologic research · 2004Review
- Zinc finger protein sall2 is not essential for embryonic and kidney development.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cancer cells may undergo loss or alterations in functions that certain viruses normally target to promote virus replication. Virus mutants that have lost the targeting function(s) should be able to grow in such cancer cells but not in normal cells. A "tumor host range" (t-hr) selection procedure has been devised and applied to polyoma virus based on this rationale. Studies of one t-hr mutant have led to the identification of the mSal2 gene product (p150(sal2)) as a binding partner of the large T antigen. mSal2 encodes a multizinc finger protein and putative transcription factor homologous to the Drosophila homeotic gene Spalt. The t-hr mutant encodes an altered large T protein that fails to interact with p150(sal2) and is defective in replication and tumor induction in newborn mice.
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