ArticleProceedings of the National Academy of Sciences of the United States of America2001
Three retrotransposon families in the genome of Giardia lamblia: two telomeric, one dead.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 130 citations in OpenAlex.
- Giardia telomeres and telomerase.Parasitology research · 2024Review
- Telomeric retrotransposons show propensity to form G-quadruplexes in various eukaryotic species.Mobile DNA · 2023Article
- Review
- The non-LTR retrotransposons of Entamoeba histolytica: genomic organization and biology.Molecular genetics and genomics : MGG · 2022Review
- Re-Discovery ofBiomedicines · 2021Article
- Drosophila: Retrotransposons Making up Telomeres.Viruses · 2017Review
- Telomerase lost?Chromosoma · 2016Review
- An epigenetic toolkit allows for diverse genome architectures in eukaryotes.Current opinion in genetics & development · 2015Review
- The landscape of transposable elements in the finished genome of the fungal wheat pathogen Mycosphaerella graminicola.BMC genomics · 2014Article
- Both endo-siRNAs and tRNA-derived small RNAs are involved in the differentiation of primitive eukaryote Giardia lamblia.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Coordination of transposon expression with DNA replication in the targeting of telomeric retrotransposons in Drosophila.The EMBO journal · 2014Article
- Structural features and mechanism of translocation of non-LTR retrotransposons in Candida albicans.Virulence · 2014Review
- The impact of cooperative social organization on reducing the prevalence of malaria and intestinal parasite infections in awramba, a rural community in South gondar, ethiopia.Interdisciplinary perspectives on infectious diseases · 2014Article
- On the origin of the eukaryotic chromosome: the role of noncanonical DNA structures in telomere evolution.Genome biology and evolution · 2013Article
- Telomere-targeted retrotransposons in the rice blast fungus Magnaporthe oryzae: agents of telomere instability.Genetics · 2012Article
- The emerging world of small silencing RNAs in protozoan parasites.Trends in parasitology · 2011Review
- The struggle for life of the genome's selfish architects.Biology direct · 2011Review
- Genome analysis and comparative genomics of a Giardia intestinalis assemblage E isolate.BMC genomics · 2010Article
- Bioinformatic analysis of Entamoeba histolytica SINE1 elements.BMC genomics · 2010Article
- A subtelomeric non-LTR retrotransposon Hebe in the bdelloid rotifer Adineta vaga is subject to inactivation by deletions but not 5' truncations.Mobile DNA · 2010Article
Corrections and comments
- Commented on by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Transposable elements inhabiting eukaryotic genomes are generally regarded either as selfish DNA, which is selectively neutral to the host organism, or as parasitic DNA, deleterious to the host. Thus far, the only agreed-upon example of beneficial eukaryotic transposons is provided by Drosophila telomere-associated retrotransposons, which transpose directly to the chromosome ends and thereby protect them from degradation. This article reports the transposon content of the genome of the protozoan Giardia lamblia, one of the earliest-branching eukaryotes. A total of three non-long terminal repeat retrotransposon families have been identified, two of which are located at the ends of chromosomes, and the third one contains exclusively dead copies with multiple internal deletions, nucleotide substitutions, and frame shifts. No other reverse transcriptase- or transposase-related sequences were found. Thus, the entire genome of this protozoan, which is not known to reproduce sexually, contains only retrotransposons that are either confined to telomeric regions and possibly beneficial, or inactivated and completely nonfunctional.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.