ArticleProceedings of the National Academy of Sciences of the United States of America2001
PAS-A domain of phosphorelay sensor kinase A: a catalytic ATP-binding domain involved in the initiation of development in Bacillus subtilis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 53 citations in OpenAlex.
- Molecular genetics of surfactin and its effects on different sub-populations ofBiotechnology reports (Amsterdam, Netherlands) · 2021Review
- Sensor kinase KinB and its pathway-associated key factors sense the signal of nutrition starvation in sporulation of Bacillus subtilis.MicrobiologyOpen · 2018Article
- The PAS domains of the major sporulation kinase in Bacillus subtilis play a role in tetramer formation that is essential for the autokinase activity.MicrobiologyOpen · 2017Article
- Crystal structure of the inactive state of the receiver domain of Spo0A from Paenisporosarcina sp. TG-14, a psychrophilic bacterium isolated from an Antarctic glacier.Journal of microbiology (Seoul, Korea) · 2017Article
- Slowdown of growth controls cellular differentiation.Molecular systems biology · 2016Article
- Multiple signals modulate the activity of the complex sensor kinase TodS.Microbial biotechnology · 2015Article
- Reductive evolution and the loss of PDC/PAS domains from the genus Staphylococcus.BMC genomics · 2013Article
- Role of the PAS sensor domains in the Bacillus subtilis sporulation kinase KinA.Journal of bacteriology · 2013Article
- Respiration control of multicellularity in Bacillus subtilis by a complex of the cytochrome chain with a membrane-embedded histidine kinase.Genes & development · 2013Article
- Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- PAS kinase: integrating nutrient sensing with nutrient partitioning.Seminars in cell & developmental biology · 2012Review
- Recent progress in Bacillus subtilis sporulation.FEMS microbiology reviews · 2012Review
- Expression level of a chimeric kinase governs entry into sporulation in Bacillus subtilis.Journal of bacteriology · 2011Article
- The threshold level of the sensor histidine kinase KinA governs entry into sporulation in Bacillus subtilis.Journal of bacteriology · 2010Article
- Systematic domain deletion analysis of the major sporulation kinase in Bacillus subtilis.Journal of bacteriology · 2010Article
- Characterization of the sporulation initiation pathway of Clostridium difficile and its role in toxin production.Journal of bacteriology · 2009Article
- In vivo domain-based functional analysis of the major sporulation sensor kinase, KinA, in Bacillus subtilis.Journal of bacteriology · 2009Article
- Regulation and function of yeast PAS kinase: a role in the maintenance of cellular integrity.Cell cycle (Georgetown, Tex.) · 2009Article
- Tricarboxylic acid cycle-dependent regulation of Staphylococcus epidermidis polysaccharide intercellular adhesin synthesis.Journal of bacteriology · 2008Article
- Phosphotransfer reactions of the CbbRRS three-protein two- component system from Rhodopseudomonas palustris CGA010 appear to be controlled by an internal molecular switch on the sensor kinase.Journal of bacteriology · 2007Article
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2 authors at 1 institution in 1 country.
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Abstract
The major sensor kinase controlling the initiation of development in Bacillus subtilis, KinA, functions by activating the phosphorelay signal-transduction system in response to as yet unknown signal ligands. KinA contains, within its amino-terminal signal-sensing region, three PAS domains that, in other proteins, are known to be involved in sensing changes in oxygen concentration and redox potential among other functions. The most amino-terminal PAS domain, PAS-A, was found to bind ATP and catalyze exchange of phosphate between ATP and nucleoside diphosphates. A cysteine-to-alanine mutation in PAS-A increased the affinity for ATP 5-fold, decreased the exchange reaction 2-fold, and stimulated KinA-dependent sporulation. A model for the role of ATP and the exchange reaction in the PAS domain in sensor kinase signal transduction is presented in which the free energy of nucleotide hydrolysis drives the conformational changes that activate or deactivate the sensor kinase in response to signal ligand binding.
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