ArticleThe Journal of experimental medicine2001
A mediator role for metallothionein in tumor necrosis factor-induced lethal shock.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Lithium Biological Action Mechanisms after Ischemic Stroke.Life (Basel, Switzerland) · 2022Review
- Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium.EMBO molecular medicine · 2020Article
- Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor.Frontiers in immunology · 2019Review
- Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling.Inflammopharmacology · 2017Review
- TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction.Mucosal immunology · 2015Article
- Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease.Cellular and molecular life sciences : CMLS · 2012Article
- Hemorrhagic shock and surgical stress alter distribution of labile zinc within high- and low-molecular-weight plasma fractions.Shock (Augusta, Ga.) · 2012Article
- Sulfur mustard induces expression of metallothionein-1A in human airway epithelial cells.International journal of general medicine · 2011Article
- Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis.Critical care medicine · 2009Article
- Evidence for a potential role of metallothioneins in inflammatory bowel diseases.Mediators of inflammation · 2009Review
- Metallothionein as an anti-inflammatory mediator.Mediators of inflammation · 2009Review
- Impact of overexpression of metallothionein-1 on cell cycle progression and zinc toxicity.American journal of physiology. Cell physiology · 2008Article
- Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-beta1 gene.Comparative hepatology · 2007Article
- Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans.Immunity & ageing : I & A · 2007Article
- Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome.Physiological genomics · 2007Article
- Protective role of metallothionein in acute lung injury induced by bacterial endotoxin.Thorax · 2004Article
- Toxicogenomic effects of marine brevetoxins in liver and brain of mouse.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2003Article
- Metallothionein (I+II) confers, via c-myc, immune plasticity in oldest mice: model of partial hepatectomy/liver regeneration.Mechanisms of ageing and developmentArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor necrosis factor (TNF) is a proinflammatory cytokine, which is centrally involved in several inflammatory disorders. Administration of TNF leads to a potentially lethal systemic inflammatory response syndrome (SIRS). We observed that (a) mice lacking functional genes for metallothionein 1 and 2 (MT-null) were protected compared with wild-type controls (P = 0.0078), and (b) mice overexpressing MT-1 (MT-TG) were more sensitized for the lethal effect of TNF than control mice (P = 0.0003), indicating a mediating role for MT in TNF induced SIRS. As MT is involved in the body zinc homeostasis, we tested whether zinc-deprivation or -supplementation alters the response to TNF. Although zinc-depletion strongly sensitized (P = 0.036), and pretreatment with zinc sulfate (ZnSO4) conferred protection against the deleterious effects of TNF (P < 0.0002), it was also found that the protection provided by zinc is independent of MT. Our observation that hsp70 is strongly induced in jejunum after ZnSO4 treatment, suggests a contribution of hsp70 in the protection against TNF. In addition, ZnSO4 cotreatment allowed complete regression of inoculated tumors with TNF and interferon gamma, leading to a significantly better survival (P = 0.0045).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.