ArticleThe Journal of clinical investigation2001
Glomerulosclerosis is transmitted by bone marrow-derived mesangial cell progenitors.
Article in The Journal of clinical investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 129 citations in OpenAlex.
- Effect of Everolimus versus Bone Marrow-Derived Stem Cells on Glomerular Injury in a Rat Model of Glomerulonephritis: A Preventive, Predictive and Personalized Implication.International journal of molecular sciences · 2021Article
- Article
- Cell-based therapy for kidney disease.Korean journal of urology · 2015Review
- The Role of Bone Marrow Cells in the Phenotypic Changes Associated with Diabetic Nephropathy.PloS one · 2015Article
- Rodent animal models: from mild to advanced stages of diabetic nephropathy.Inflammopharmacology · 2014Review
- In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration.Cell reports · 2014Article
- The role of bone marrow derived-mesenchymal stem cells in attenuation of kidney function in rats with diabetic nephropathy.Diabetology & metabolic syndrome · 2014Article
- Regenerative medicine for the kidney: renotropic factors, renal stem/progenitor cells, and stem cell therapy.BioMed research international · 2014Review
- Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser-induced choroidal neovascularization.Investigative ophthalmology & visual science · 2013Article
- Effect of mesenchymal stem cells on anti-Thy1,1 induced kidney injury in albino rats.Asian Pacific journal of tropical biomedicine · 2013Article
- Heme oxygenase effect on mesenchymal stem cells action on experimental Alzheimer's disease.EXCLI journal · 2013Article
- Differential expression of laminin isoforms in diabetic nephropathy and other renal diseases.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2012Article
- Mesenchymal stem cells as a therapeutic approach to glomerular diseases: benefits and risks.Kidney international supplements · 2011Review
- Kidney repair and stem cells: a complex and controversial process.Pediatric nephrology (Berlin, Germany) · 2011Review
- Identifying advanced glycation end products as a major source of oxidants in aging: implications for the management and/or prevention of reduced renal function in elderly persons.Seminars in nephrology · 2009Article
- Review article: endothelial progenitor cells in renal disease.Nephrology (Carlton, Vic.) · 2009Review
- Adoptive transfer of syngeneic bone marrow-derived cells in mice with obesity-induced diabetes: selenoorganic antioxidant ebselen restores stem cell competence.The American journal of pathology · 2009Article
- What is the significance of CD34 immunostaining in the extraglomerular and intraglomerular mesangium?Virchows Archiv : an international journal of pathology · 2008Article
- Involvement of bone marrow-derived endothelial progenitor cells in glomerular capillary repair in habu snake venom-induced glomerulonephritis.Virchows Archiv : an international journal of pathology · 2008Article
- Long-term engraftment of bone marrow-derived cells in the intimal hyperplasia lesion of autologous vein grafts.The American journal of pathology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We found that ROP Os/+ (Os/+) mice had diffuse glomerulosclerosis and glomerular hypertrophy and that their mesangial cells (the vascular smooth muscle cells of the glomerulus) displayed an apparent sclerosing phenotype. Since mesangial cells are the major source of scar tissue in glomerulosclerosis, we postulated that the sclerosis phenotype was carried by mesangial cell progenitors and that this phenotype could be derived from the bone marrow (BM). Therefore, we transplanted BM from Os/+ mice into congenic ROP +/+ mice (+/+ mice), which have normal glomeruli. We found that glomeruli of +/+ recipients of Os/+ marrow contained the Os/+ genotype, were hypertrophied, and contained increased extracellular matrix. Clones of recipient glomerular mesangial cells with the donor genotype were found in all +/+ recipients that developed mesangial sclerosis and glomerular hypertrophy, whereas +/+ recipients of +/+ BM had normal glomeruli. Thus, the sclerotic (Os/+) or normal (+/+) genotype and phenotype were present in, and transmitted by, BM-derived progenitors. These data show that glomerular mesangial cell progenitors are derived from the BM and can deliver a disease phenotype to normal glomeruli. Glomerular lesions may therefore be perpetuated or aggravated, rather than resolved, by newly arriving progenitor cells exhibiting a disease phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.