ArticleThe Journal of cell biology2001
A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilization.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 78 citations in OpenAlex.
- Rho family GTPase signaling through type II p21-activated kinases.Cellular and molecular life sciences : CMLS · 2022Review
- Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder.CNS neuroscience & therapeutics · 2022Article
- Article
- A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein-protein interactions.Molecular systems biology · 2022Article
- PAK5 facilitates the proliferation, invasion and migration in colorectal cancer cells.Cancer medicine · 2020Article
- A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity.Scientific reports · 2017Article
- Function of Slit/Robo signaling in breast cancer.Frontiers of medicine · 2015Review
- The overexpression of P21-activated kinase 5 (PAK5) promotes paclitaxel-chemoresistance of epithelial ovarian cancer.Molecular and cellular biochemistry · 2013Article
- P21-activated kinase 4 (PAK4) is required for metaphase spindle positioning and anchoring.Oncogene · 2013Article
- Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization.The Journal of biological chemistry · 2012Article
- Prostate-derived sterile 20-like kinases (PSKs/TAOKs) are activated in mitosis and contribute to mitotic cell rounding and spindle positioning.The Journal of biological chemistry · 2011Article
- Interaction of microtubules and actin with the N-terminus of βPix-b(L) directs cellular pinocytosis.Molecular and cellular biochemistry · 2011Article
- Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis.The Journal of cell biology · 2010Article
- Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells.The Prostate · 2010Article
- Huntingtin promotes cell survival by preventing Pak2 cleavage.Journal of cell science · 2009Article
- An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.Chemistry & biology · 2008Article
- Calpain 6 is involved in microtubule stabilization and cytoskeletal organization.Molecular and cellular biology · 2007Article
- Gene expression correlates of neurofibrillary tangles in Alzheimer's disease.Neurobiology of aging · 2006Article
- Central nervous system functions of PAK protein family: from spine morphogenesis to mental retardation.Molecular neurobiology · 2006Review
- p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B.Molecular and cellular biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coordination of the different cytoskeleton networks in the cell is of central importance for morphogenesis, organelle transport, and motility. The Rho family proteins are well characterized for their effects on the actin cytoskeleton, but increasing evidence indicates that they may also control microtubule (MT) dynamics. Here, we demonstrate that a novel Cdc42/Rac effector, X-p21-activated kinase (PAK)5, colocalizes and binds to both the actin and MT networks and that its subcellular localization is regulated during cell cycle progression. In transfected cells, X-PAK5 promotes the formation of stabilized MTs that are associated in bundles and interferes with MTs dynamics, slowing both the elongation and shrinkage rates and inducing long paused periods. X-PAK5 subcellular localization is regulated tightly, since coexpression with active Rac or Cdc42 induces its shuttling to actin-rich structures. Thus, X-PAK5 is a novel MT-associated protein that may communicate between the actin and MT networks during cellular responses to environmental conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.