ArticleThe Journal of biological chemistry2002
Cholesteryl ester is transported from caveolae to internal membranes as part of a caveolin-annexin II lipid-protein complex.
Article in The Journal of biological chemistry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 115 citations in OpenAlex.
- Occludin, caveolin-1, and Alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- SR-BI mediates neutral lipid sorting from LDL to lipid droplets and facilitates their formation.PloS one · 2020Article
- Review
- Annexin A3 Regulates Early Blood Vessel Formation.PloS one · 2015Article
- The Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments.Journal of molecular biochemistry · 2014Article
- An association of metabolic syndrome constellation with cellular membrane caveolae.Pathobiology of aging & age related diseases · 2014Review
- Annexin A2 regulates β1 integrin internalization and intestinal epithelial cell migration.The Journal of biological chemistry · 2013Article
- Review
- Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance.British journal of pharmacology · 2011Review
- Regulation of alpha1 Na/K-ATPase expression by cholesterol.The Journal of biological chemistry · 2011Article
- The role of caveolae in endothelial cell dysfunction with a focus on nutrition and environmental toxicants.Journal of cellular and molecular medicine · 2010Review
- HIV infection upregulates caveolin 1 expression to restrict virus production.Journal of virology · 2010Article
- Article
- Intracellular lipid droplets contain dynamic pools of sphingomyelin: ADRP binds phospholipids with high affinity.Lipids · 2010Article
- Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones.Nutrition & metabolism · 2010Article
- Lipids and membrane lateral organization.Frontiers in physiology · 2010Article
- The annexins: spatial and temporal coordination of signaling events during cellular stress.Cellular and molecular life sciences : CMLS · 2009Review
- Regulation of intracellular cholesterol distribution by Na/K-ATPase.The Journal of biological chemistry · 2009Article
- Lipid droplets: a classic organelle with new outfits.Histochemistry and cell biology · 2008Review
- Caveolae structure and function.Journal of cellular and molecular medicine · 2008Review
Corrections and comments
- Retraction · 2013-03-01Falsification/Fabrication of Image · Investigation by Company/Institution · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · NIH misconduct finding for Eric J Smart
- Commented on by
- Commented on by
- Retracted
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We previously demonstrated that in Chinese hamster ovary cells scavenger receptor, class B, type I-dependent selective cholesteryl ester uptake occurs in caveolae. In the present study we hypothesized that cholesteryl ester is transported from caveolae through the cytosol to an internal membrane by a caveolin chaperone complex similar to the one we originally described for the transport of newly synthesized cholesterol. To test this hypothesis we incubated Chinese hamster ovary cells expressing scavenger receptor, class B, type I with [(3)H]cholesteryl ester-labeled high density lipoprotein, subfractionated the cells and looked for a cytosolic pool of [(3)H]cholesteryl ester. The radiolabeled sterol initially appeared in the caveolae fraction, then in the cytosol, and finally in the internal membrane fraction. Caveolin IgG precipitated all of the [(3)H]cholesteryl ester associated with the cytosol. Co-immunoprecipitation studies demonstrated that in the presence of high density lipoprotein, but not low density lipoprotein or lipoprotein-deficient serum, caveolin IgG precipitated four proteins: annexin II, cyclophilin 40, caveolin, and cyclophilin A. Caveolin acylation-deficient mutants were used to demonstrate that acylation of cysteine 133 but not cysteine 143 or 156 is required for annexin II association with caveolin and the rapid transport of cholesteryl esters out of caveolae. We conclude that a caveolin-annexin II lipid-protein complex facilitates the rapid internalization of cholesteryl esters from caveolae.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.