ArticleThe American journal of pathology2001
A dominant interference collagen X mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- How cell migration helps immune sentinels.Frontiers in cell and developmental biology · 2022Review
- Defective endochondral ossification-derived matrix and bone cells alter the lymphopoietic niche in collagen X mouse models.Stem cells and development · 2013Article
- Extracellular matrix degradation and remodeling in development and disease.Cold Spring Harbor perspectives in biology · 2011Review
- Congenic mice confirm that collagen X is required for proper hematopoietic development.PloS one · 2010Article
- Beta-catenin, cartilage, and osteoarthritis.Annals of the New York Academy of Sciences · 2010Review
- Survey of the enthesopathy of X-linked hypophosphatemia and its characterization in Hyp mice.Calcified tissue international · 2009Article
- Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.Experimental cell research · 2009Article
- Altered endochondral ossification in collagen X mouse models leads to impaired immune responses.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Heparan sulfate proteoglycans: a GAGgle of skeletal-hematopoietic regulators.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Review
- Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function.PLoS biology · 2007Article
- A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation.The Journal of biological chemistry · 2005Article
- Matrix remodeling during endochondral ossification.Trends in cell biology · 2004Review
- Chicken collagen X regulatory sequences restrict transgene expression to hypertrophic cartilage in mice.The American journal of pathology · 2004Article
- Linking hematopoiesis to endochondral skeletogenesis through analysis of mice transgenic for collagen X.The American journal of pathology · 2002Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Collagen X transgenic (Tg) mice displayed skeleto-hematopoietic defects in tissues derived by endochondral skeletogenesis.(1) Here we demonstrate that co-expression of the transgene product containing truncated chicken collagen X with full-length mouse collagen X in a cell-free translation system yielded chicken-mouse hybrid trimers and truncated chicken homotrimers; this indicated that the mutant could assemble with endogenous collagen X and thus had potential for dominant interference. Moreover, species-specific collagen X antibodies co-localized the transgene product with endogenous collagen X to hypertrophic cartilage in growth plates and ossification centers; proliferative chondrocytes also stained diffusely. Electron microscopy revealed a disrupted hexagonal lattice network in the hypertrophic chondrocyte pericellular matrix in Tg growth plates, as well as altered mineral deposition. Ruthenium hexamine trichloride-positive aggregates, likely glycosaminoglycans (GAGs)/proteoglycans (PGs), were also dispersed throughout the chondro-osseous junction. These defects likely resulted from transgene co-localization and dominant interference with endogenous collagen X. Moreover, altered GAG/PG distribution in growth plates of both collagen X Tg and null mice was confirmed by a paucity of staining for hyaluronan and heparan sulfate PG. A provocative hypothesis links the disruption of the collagen X pericellular network and GAG/PG decompartmentalization to the potential locus for hematopoietic failure in the collagen X mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.